{"product_id":"cationic-polymers-based-non-viral-gene-carriers-von-atul-pathak-und-kailash-c-gupta","title":"Cationic Polymers based Non-viral Gene Carriers","description":"\u003cp\u003eNucleic acids-based next generation  biopharmaceuticals (i.e., oligonucleotides,  siRNA) are potential therapeutic agents have ability  to cope with various incurable diseases. However,  several biological barriers present a challenge for  efficient gene delivery. Inception of nanotechnology  now offer numerous non-viral vectors that have been  fabricated and found capable of transmitting the  biopharmaceuticals into the cell and even into  specific subcellular compartments like mitochondria.  This book illustrates novel chemically modified  polyallylamine and polyethylenimine based nano- vectors for enhanced gene delivery. Modification of  these polymers using imidazolyl and polysaccharides  such as hyaluronic acid, chondroitin sulfate and  heparin not only improve cytotoxicity index but also  provides site-specificity for cell-type specific gene  delivery. Incorporation of targeting moiety minimizes  the chance of potential adverse effects and also  reduces the amount the amount of dose required to  achieve desired therapeutic effects. Recent  developments in formulation of efficient drug  carriers showed potential to develop gene therapy  again diseases like cancer.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843376198\"\u003e\u003ch3\u003ePharmaceutical Applications of Nano-vectors in Transfection Technology\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843376198","offer_id":39497052520541,"sku":"9783843376198","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/e938d4d7-d891-41d0-948f-59f6d82c52b0.jpg?v=1757656980","url":"https:\/\/shop.autorenwelt.de\/products\/cationic-polymers-based-non-viral-gene-carriers-von-atul-pathak-und-kailash-c-gupta","provider":"Autorenwelt Shop","version":"1.0","type":"link"}