{"product_id":"cardiovascular-effects-of-leonotis-leonurus-in-anesthesized-rats-von-noxolo-doris-tshambuluka-pierre-mugabo-und-ivan-green","title":"Cardiovascular effects of Leonotis Leonurus in anesthesized rats","description":"\u003cp\u003eThis study evaluates the hypotensive properties and  the mechanism of action of the aqueous leaf extract  of Leonotis Leonurus in anesthetized male Wistar  rats, using computerized blood pressure recording  system. The effect of aqueous leaf extract of L.  leonurus on the blood pressure was investigated by  infusing intravenous doses of 200 mg\/kg to 1g\/kg  into anesthetized rats. Its underlying blood  pressure lowering mechanism was also studied by  challenging the parasympathetic, sympathetic and  muscarinic systems of anesthetized rats by  pretreating with, dobutamine, atenolol, and  atropine. Pretreating the animals with reserpine  and L. leonurus was also employed in order to  challenge the adrenal system of rats. The results showed that the aqueous leaf extract of  Leonotis leonurus produces a dose dependent fall in  the systolic blood pressure, diastolic blood  pressure and heart rate of the rats. This effect on  heart rate may suggest the involvement of ¿- adrenergic receptors in the cardiac effect of L.  leonurus.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844320466\"\u003e\u003ch3\u003eCardiovascular effects of aqueous leaf extract of Leonotis leonurus in anesthesized Wistar rats\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844320466","offer_id":39470135738461,"sku":"9783844320466","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/1edef788-99c2-4d0e-afed-b12a92cf400d.jpg?v=1758952115","url":"https:\/\/shop.autorenwelt.de\/products\/cardiovascular-effects-of-leonotis-leonurus-in-anesthesized-rats-von-noxolo-doris-tshambuluka-pierre-mugabo-und-ivan-green","provider":"Autorenwelt Shop","version":"1.0","type":"link"}