{"product_id":"cap-independent-translation-von-peter-sarnow-hrsg","title":"Cap-Independent Translation","description":"\u003cp\u003eWhether or not an mRNA is translated is often thought to be a simple function of its steady-state concentration and the ab­ sence of inhibitory proteins or RNA structures in the 5' and 3' noncoding regions. The articles presented in this volume show an unexpected flexibility of the eukaryotic translational appara­ tus in the mechanism of translational initiation and provide new opportunities for regulation. Most or all mRNA molecules synthesized by RNA poly­ 7 merase II in eukaryotic cells contain a 5' terminal mGpppG dinucleotide, also known as the \"cap structure. \" RNAs carrying a cap structure have been shown to be more resistant to attack by exoribonucleases than their uncapped counterparts. Further­ more, the cap facilitates transport of the RNAs from the nucleus to the cytoplasm. In the cytoplasm, the cap functions as a binding site for the cap binding protein complex eIF-4, which enhances the translation of the RNAs by the eukaryotic trans­ lational apparatus. Specifically, it has been postulated that bind­ ing of e1F-4 to the 5' terminal cap facilitates the recruitment of ribosomal subunits onto the mRNAs via their free 5' ends (cap­ dependent translation). Accordingly, uncapped RNAs are generally translated more poorly than capped RNAs. However, during the past 6 years both viral and cellular mRNAs have been discovered that can be translated cap-independently.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783642796654\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783642796654","offer_id":39432057454685,"sku":"9783642796654","price":106.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/693d4d33-fea0-4e31-9cc6-1f8f04d86f56.jpg?v=1775105235","url":"https:\/\/shop.autorenwelt.de\/products\/cap-independent-translation-von-peter-sarnow-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}