{"product_id":"calcium-regulation-by-calcium-binding-proteins-in-neurodegenerative-disorders-von-katharina-braun-claus-w-heizmann","title":"Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders","description":"\u003cp\u003eClaus W. Heizmann and Katharina Braun ore than 10,000 articles were published in 1994 on calcium, M 2 emphasizing the widespread interest and progress in Ca +­ 2 related research. This book focuses mainly on Ca + -binding pro­ 2 teins in the central nervous system, where Ca + ions have been found to activate fundamental processes such as release of neu­ rotransmitters, axonal flow, long term potentiation, cell motility, differentiation, secretion, and apoptosis. It has also been found that a number of neurodegenerative disorders have been attributed 2 1 to aberrations of intracellular Ca + homeostasis. 2 2 Intracellular Ca + levels and Ca + signaling within cells must 2 3 2 be tightly controlled. ¿ Ca + overload as a result of seizures or ischemia is supposed to activate biochemical processes, leading to enzymatic breakdown of proteins and lipids, malfunctioning of 2 mitochondria, energy failure and ultimately cell death. There is 3 experimental evidence that electrically induced irreversible depo­ larization of hippocampal neurons, which may be an early indica­ 2 tion of neuronal damage, could be prevented by injecting Ca + chelators and thereby increasing intracellular buffering capacity. Thus, it is reasonable to assume that neurons containing certain 2 intracellular Ca +-binding proteins, and therefore having a greater 2 capacity to buffer Ca +, could be more resistant to degeneration.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783662216910\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783662216910","offer_id":39441754325085,"sku":"9783662216910","price":53.49,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/5e677d06-7601-42ce-a874-92282bfb9719.jpg?v=1753590528","url":"https:\/\/shop.autorenwelt.de\/products\/calcium-regulation-by-calcium-binding-proteins-in-neurodegenerative-disorders-von-katharina-braun-claus-w-heizmann","provider":"Autorenwelt Shop","version":"1.0","type":"link"}