{"product_id":"calcium-entry-blockers-in-cardiovascular-and-cerebral-dysfunctions-von-t-godfraind-a-g-herman-d-wellens-hrsg","title":"Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions","description":"2 The free internal Ca+ concentration in human red cells is set according to the leak 2 and-pump principle: There is a finite passive Ca+ influx at the physiological 2 2 Ca+ -gradient across the membrane which is compensated by Ca+ pumping in the outward direction with a rate given by the degree of saturation of the A TP-fuelled Ca 2 pump at the steady-state internal Ca+ concentration. Simons (1982) recently devised a method allowing the measurement of the steady 2 2 state internal Ca+ concentration. Cells are suspended in media of different Ca+ con 2 2 tent whose Ca+ concentration is monitored by a Ca+ -selective electrode. When the cells are lysed (by digitonin) there is an upward or downward deflection of the elec 2 trode signal. At the point of zero deflection, the cellular Ca+ concentration equals that 2 of the medium. The result is, that in fresh human red blood cells the Ca+ concentra tion is ;;;; O.4,uM (this is an upper estimate; the true value may be considerably lower).\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9789400960350\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9789400960350","offer_id":39415748034653,"sku":"9789400960350","price":53.49,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/99c42b4a-515d-4aa5-8808-44b3b36cac1b.jpg?v=1775110232","url":"https:\/\/shop.autorenwelt.de\/products\/calcium-entry-blockers-in-cardiovascular-and-cerebral-dysfunctions-von-t-godfraind-a-g-herman-d-wellens-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}