{"product_id":"brain-from-development-to-neoplasia-and-gene-therapy-solution-von-jerzy-trojan","title":"Brain - from Development to Neoplasia, and Gene Therapy Solution","description":"\u003cp\u003eDifferentiation of nervous tissue, which occurs during CNS development, was first described in detail while investigating a model of rat brain through the use of a new biomarker known as alpha-fetoprotein, AFP. During this research, another model -mouse teratocarcinoma - enabled the description of the different steps of nervous tissue formation following distinct pathological ways of CNS development. Comparing these two processes gave rise to the following conclusions: a striking convergence exists between normal and neoplastic nervous tissue development and correlates with the presence of oncoproteins such as AFP and growth factor IGF-I. These interesting observations have oriented the pursuit of one goal: stopping the neoplastic CNS development conducing to the malignant tumor - glioblastoma. From this endeavor, stemmed an efficient anti-gene strategy targeting gene of growth factor IGF-I present in brain tumor development, inducing immune anti-tumor response and consequently, increasing the median survival of glioblastoma patients up to 2 years.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786202080248\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786202080248","offer_id":39460081795165,"sku":"9786202080248","price":64.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/e87c76b9-8ad2-4833-bbb6-ce41f05f4f62.jpg?v=1770445396","url":"https:\/\/shop.autorenwelt.de\/products\/brain-from-development-to-neoplasia-and-gene-therapy-solution-von-jerzy-trojan","provider":"Autorenwelt Shop","version":"1.0","type":"link"}