{"product_id":"bovine-trophoblast-non-classical-mhc-class-i-proteins-von-parveen-parasar","title":"Bovine Trophoblast Non-classical MHC Class I Proteins","description":"\u003cp\u003eExtremely polymorphic and ubiquitously expressed classical MHC-I (MHC-Ia) proteins, which present the foreign antigenic peptides to CD8+ T lymphocytes, are involved in acceptance or rejection of tissue grafts based on the degree of similarity of these proteins among the cells of donor and recipient. Discovery of non-classical MHC-I proteins such as Human Leukocyte Antigen-G (HLA-G) in humans and Qa-2 in mice, led to a new paradigm of immune tolerance to fetus. Class-Ib proteins are important glycoproteins which are important modulators of maternal immune system during pregnancy. During third trimester, bovine fetal trophoblast cells express both MHC-Ia and MHC-Ib proteins, which suggests that these proteins play a role in separation of the fetal placenta during parturition. The MHC-Ib proteins expressed during third trimester are bovine leukocyte antigen (BoLA) NC1*00401, NC1*00501, NC2*00102, NC3*00101 and NC4*00201 proteins.N*01701, N*01802, NC1*00501, NC3*00101 and NC4*00201 proteins showed the cell-surface expression as identified with transfection assays performed in murine P815 and human K562 cells.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659915147\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659915147","offer_id":39450377683037,"sku":"9783659915147","price":55.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/ef50093e-6315-46e9-87c0-05ebf9f42353.jpg?v=1769492804","url":"https:\/\/shop.autorenwelt.de\/products\/bovine-trophoblast-non-classical-mhc-class-i-proteins-von-parveen-parasar","provider":"Autorenwelt Shop","version":"1.0","type":"link"}