{"product_id":"biomimetic-scaffolds-for-ligament-tissue-engineering-von-denver-surrao","title":"Biomimetic Scaffolds For Ligament Tissue Engineering","description":"\u003cp\u003eThe primary objective of my thesis was to investigate the effect of crimp-like fibrous scaffolds on bovine fibroblasts and to develop a scaffold for anterior cruciate ligament (ACL) tissue engineering. To achieve this objective, fibrous biodegradable polymeric scaffolds were fabricated, which upon relaxation developed a crimp-like structure, which resembled the crimp seen in native collagen. The understanding of the crimp mechanism allowed for controlling crimp-like patterns in various polymer fibre systems. The benefit of crimp was evaluated by seeding fibroblasts on crimp-like fibres that were subjected to dynamic mechanical loading. The results showed a significant increase in extracellular matrix (ECM) accumulation by fibroblasts that experienced crimp unfolding. In addition, fibroblasts seeded on mechanically stimulated crimp-like fibrous scaffolds formed ECM bundles that resembled collagen fibre fascicles. From the results obtained it is evident that crimp and its unfolding are key design features\/conditioning techniques that need to be incorporated into fibrous scaffolds that possess high modulus, intended for ligament tissue engineering.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659291166\"\u003e\u003ch3\u003eLigament Tissue Engineering\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783659291166","offer_id":39486424416349,"sku":"9783659291166","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/dfeaaed3-56f4-4877-81dd-78802358d2eb.jpg?v=1770360716","url":"https:\/\/shop.autorenwelt.de\/products\/biomimetic-scaffolds-for-ligament-tissue-engineering-von-denver-surrao","provider":"Autorenwelt Shop","version":"1.0","type":"link"}