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A biomarker is a substance used as an indicator of a biologic state. It is a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Biomarker is a parameter that can be used to measure the progress of disease or the effects of treatment. Key features . Theoretical approaches, number of examples and references . Provides a broad, application-oriented overview . Real application scenarios, such as biomarkers projects that require the use of a whole set of drug design tools . This appears to be an excellent series of textbooks for students, researchers and scientists . Provides a comprehensive, definitive, and up to date reference of the main areas of specialist and expert knowledge and skills used by those involved in all aspects of the new drug development research . Illustrations help readers understand the research methodology easily . Lists of Web resources serve as a gateway to important research centers, institutes, and other sources of information