{"product_id":"biomarkers-and-genetics-in-alzheimers-disease-von-mariem-mhiri","title":"Biomarkers and genetics in Alzheimer's disease","description":"\u003cp\u003eCSF biomarkers and genetic studies of ApoE make a major contribution to the positive diagnosis of Alzheimer's disease. Our aim was to compare the clinical data, biological and genetic results of the AD population with a group of patients with non-Alzheimer's dementia (D n-MA) and a control population. Methods: This was a retrospective analytical study conducted at the neurology department of the Sahloul University Hospital in Sousse over 3 years (January 2015-December 2017) and included 227 patients meeting the DSM-5 criteria for TNC. The aetiological diagnosis was based on international criteria established through neuropsychological assessment, imaging, CSF biomarker testing and ApoE polymorphism study. Results: The mean age of onset of AD was 70.79 ± 8.93 years. An early age of onset (\u0026lt;65 years) was found in 21.9% of cases. The sex ratio was 1. Decreased concentrations of AB40 and AB42 were found in the AD group, with sensitivity of 82% and 86% respectively, and specificity of 85% and 83%. Total Tau and P181-Tau protein concentrations were higher.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786207409266\"\u003e\u003ch3\u003eComparative study\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786207409266","offer_id":48531554206021,"sku":"9786207409266","price":79.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/5a2e4820-ed3b-4035-b682-5e35c39c8ad3.jpg?v=1747982312","url":"https:\/\/shop.autorenwelt.de\/products\/biomarkers-and-genetics-in-alzheimers-disease-von-mariem-mhiri","provider":"Autorenwelt Shop","version":"1.0","type":"link"}