{"product_id":"biochemistry-and-genetics-of-recq-helicases-von-david-b-lombard","title":"Biochemistry and Genetics of Recq-Helicases","description":"\n                \u003cem\u003eBiochemistry And Genetics of RecQ-Helicases\u003c\/em\u003e provides a  background into the role of helicases in general and RecQ helicases  specifically in DNA repair. Helicases- enzymes which break down  hydrogen bonds between nucleic acid strands in a nucleoside  triphosphate-dependent manner-are ubiquitous in biology, participating  in processes as diverse as replication, repair, recombination,  transcription, and translation. The RecQ-family helicases are a group  of helicases which have important roles in the maintenance of genomic  stability in many organisms. In humans, mutations in three RecQ-family  helicases lead to disease. This book thoroughly examines these  helicases. Mutations in the BLM gene lead to Bloom syndrome, a  disorder characterized by a susceptibility to many types of cancer.  Mutations in the WRN gene cause Werner syndrome, a disease which in  some respects resembles premature aging. Finally, mutations in a newly  characterized RecQ-family member, RECQ4, may lead to the very rare  recessive disorder Rothmund-Thomson syndrome, a condition  characterized by developmental abnormalities and some aging-like  manifestations. This book is intended for any researchers invested in  these particular disorders, or with a general interest in DNA.\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9781461355373\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9781461355373","offer_id":39415358390365,"sku":"9781461355373","price":106.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/1aced38b-c5f4-4d1d-9c1d-0b1fa2985046.jpg?v=1763443448","url":"https:\/\/shop.autorenwelt.de\/products\/biochemistry-and-genetics-of-recq-helicases-von-david-b-lombard","provider":"Autorenwelt Shop","version":"1.0","type":"link"}