{"product_id":"bicyclo2-2-1-heptane-carboxamides-von-martin-thuo-mwangi","title":"Bicyclo[2.2.1] heptane-carboxamides","description":"\u003cp\u003eThis book summarizes efforts toward the chiral  synthesis of norcamphor and analogues. Intermediate  amide was resolved and X-ray structure of the  enantiomers solved. The absolute configuration of  the ketones was inferred from that of corresponding  amide precursor. The conversion of the precursors to  the ketones was performed and proved to be  stereospecific. This was based on the hydrolysis of  chloronitriles to ketones via amides. Since chlorine  gives anomalous dispersion of X-rays, the  chlorinated intermediates could be used to assign  absolute configuration of the ketones. The generated  synthesized chiral ketones play a critical role in  the synthesis of disubstituted cyclopentanes as  demonstrated in the synthesis of stereoselective  hydroxylation of the bicyclic amides and subsequent  ketonization. Lactonization followed by hydrolysis  gives a cyclopentane with 3 or 4 well defined  stereogenic centers.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838328003\"\u003e\u003ch3\u003ePathway to chiral ketones and cyclopentanes\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838328003","offer_id":39499063525469,"sku":"9783838328003","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/16a16b0e-6c8f-4b59-a3c1-8428611115b7.jpg?v=1757825280","url":"https:\/\/shop.autorenwelt.de\/products\/bicyclo2-2-1-heptane-carboxamides-von-martin-thuo-mwangi","provider":"Autorenwelt Shop","version":"1.0","type":"link"}