{"product_id":"berberine-an-alternative-treatment-for-lung-cancer-von-madhusudhanan-madhusudhanan-thiyagarajan-und-balasubramanian","title":"Berberine - An alternative treatment for lung cancer","description":"\u003cp\u003eIn the present investigation, the efficacy of  berberine in human lung carcinoma cell line (A549)  and experimental lung cancer were studied. The  viability of A549 cells was significantly reduced by  berberine treatment, indicating that the treatment is  cytotoxic. This was confirmed from the results that  levels of marker enzymes and synthesis of nucleic  acids were reduced on berberine treatment.Similarly  the increased level of intra cellular calcium, p53  protein expression and cytochrome C paves the way for  caspases activation; thereby induction of apoptosis  and cell cycle arrest ensues that indicates the anti- proliferative potential and anticancer activity of  berberine. Moreover, on berberine treatment, the lung  cancer bearing animals have showed significant  increase in body and organ weight. The lipid  peroxidation and glycoproteins levels were decreased  on treatment. Altered activities of membrane bound  ATPase, Phase I biotransformation enzymes and the  levels of ICDH, SDH, MDH and ¿ ¿ KGDH due to  mitochondrial damage were noticeably reverted back to  near normal in treated animals. Histopathological  studies confirm the recovery from the neoplastic  conditions.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838399607\"\u003e\u003ch3\u003eEffect of berberine on human lung carcinoma cell line (A549) and experimental lung cancer\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838399607","offer_id":39493496832093,"sku":"9783838399607","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/88a948d2-fa3a-4097-92c9-9f11b5c340b8.jpg?v=1775626952","url":"https:\/\/shop.autorenwelt.de\/products\/berberine-an-alternative-treatment-for-lung-cancer-von-madhusudhanan-madhusudhanan-thiyagarajan-und-balasubramanian","provider":"Autorenwelt Shop","version":"1.0","type":"link"}