Rheumatoid arthritis is progressive, autoimmune inflammatory chronic disorder which do not have curative treatment yet. Aryl and hetero-aryl acids has maximum share of anti-inflammatory drugs in the therapeutics today as non steroidal anti-inflammatory drugs (NSAIDs). Benzimidazole moiety with heteroaryl and psudoacedic nature is promising moiety for development of NSAIDs. In the present project, synthesis, pharmacological evaluation, probable mechanism of action and quantitative structure-activity relationship (QSAR) of benzmidazole-2-carboxylic acids are reported. The excellent efficacy and safety was observed for benzimidaxole-2-carboxylic acid derivatives in laboratory animal models of inflammation and rheumatoid arthritis without side-effect of gastrointestinal disturbances. The reliving effects against pain and fever in experimental animal models suggested promise as potential NSAID.
Tags: Medizin, Pharmazie
Taschenbuch - 9783843372367 Verlag: LAP Lambert Acad. Publ. Ersterscheinung: Juli 2011 ISBN-13: 9783843372367 Größe: 220 mm x 150 mm x 7 mm Gewicht: 201 Gramm 124 Seiten Versandfertig in 3-5 Tagen.