{"product_id":"b-cell-specificity-and-pattern-in-primary-sjogrens-syndrome-studies-in-humans-and-a-murine-model-von-lara-a-aqrawi","title":"B cell specificity and pattern in primary Sjögren's syndrome","description":"\u003cp\u003eSjögren¿s syndrome (SS) is a chronic autoimmune disease characterised by focal inflammation of the salivary and lacrimal glands, resulting in the common symptoms of dry eyes and dry mouth. Here, mononuclear cells, including B cells, infiltrate the glands, leading to their dysfunction and later destruction. Another distinctive feature is the systemic production of autoantibodies that results from the activation of B cells into antibody secreting plasma cells. Hence, although the etiology of SS remains unclear, B cells do play an important part in the pathogenesis of this disease. In this doctoral work we explore the immunological process, while addressing the concept of B cell specificity and pattern in primary SS (pSS). We consider both the general and the autoantigen-specific B cell pattern in the peripheral blood and the salivary glands of patients with pSS, and also account for the expression pattern of the Ro52 autoantigen. Furthermore, we explore a congenic NOD mouse strain, namely NOD.B10.H2b, in order to characterise the plasma cell compartment in the parotid and submandibular salivary glands and in the bone marrow.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786202300223\"\u003e\u003ch3\u003eStudies in humans and a murine model\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786202300223","offer_id":39465854009437,"sku":"9786202300223","price":59.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/9c990d1f-e520-4f28-9d9e-9d4151c86790.jpg?v=1769233181","url":"https:\/\/shop.autorenwelt.de\/products\/b-cell-specificity-and-pattern-in-primary-sjogrens-syndrome-studies-in-humans-and-a-murine-model-von-lara-a-aqrawi","provider":"Autorenwelt Shop","version":"1.0","type":"link"}