{"product_id":"autonomous-effects-of-shear-and-stretch-on-the-arterial-wall-von-tyler-thacher","title":"Autonomous effects of shear and stretch on the arterial wall","description":"\u003cp\u003eDue to the pulsatile nature of blood flow, arteries  are constantly exposed to dynamic mechanical forces;  the pulsatility continuously stretches the vessel  wall and the flow creates a frictional force on the  interior surface. These stresses, referred to as  cyclic circumferential stretch and shear stress, are  known to determine arterial structure and  morphology; modulation of which leads to the  progression of vascular diseases such as  hypertension and atherosclerosis. Yet the individual  contributions of cyclic stretch and shear stress,  with regards to vascular disease, have yet to be  revealed.   In this book I wish to identify the role of reduced  cyclic stretch in the development of endothelial  dysfunction and vascular remodeling, develop an  experimental model for studying the autonomous  effects of shear stress and cyclic stretch and how  these two stimuli individually modulate markers of  vascular disease in different regions of the  vascular wall.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838367118\"\u003e\u003ch3\u003eHow hemodynamic forces effect of the progression of vascular disease\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838367118","offer_id":39469279215709,"sku":"9783838367118","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/94c5ddad-e512-458e-849a-e11306535b81.jpg?v=1757825492","url":"https:\/\/shop.autorenwelt.de\/products\/autonomous-effects-of-shear-and-stretch-on-the-arterial-wall-von-tyler-thacher","provider":"Autorenwelt Shop","version":"1.0","type":"link"}