{"product_id":"autoimmunity-von-andrzej-gorski-hubert-krotkiewski-michal-zimecki-hrsg","title":"Autoimmunity","description":"\u003cp\u003eThe immune system has evolved mechanisms enabli ng it to discriminate between self and non-self constituents. A normally functioning organism is naturally unresponsive to self antigens originating from clonal deletion, aner­ gy, or an active suppression of self-reactive T cells. The wide spectrum of autoimmune responses may be divided into systemic and organ-specific dis­ eases and encompasses the actions of autoantibodies, autoantigeu-autoanti­ body complexes, and sensitized T lymphocytes. The aim of this book is to review the current understandin g, concepts and hypotheses regarding the pathogenesis and therapeutic approaches in autoim­ mune disorders. The first six articles are generally concerned with the mech­ anisms operating in autoimmune phenomena, whereas the subsequent reviews discuss particular phenomena in representative autoimmune dis­ eases. The introductory article underlines the significance of the interactions between antigen-specific T cells and other elements ot the immune system and proposes that not suppression, but rather activation of the immune sys­ tem, leading to a redirection of the immune response, would be therapeuti­ cally beneficial. The next articles present the importance of costim ulatory signals in determining various types of immune responses, including autoim­ munity, and the role of regulatory T cells. Further, an interesting phenome­ non of epitope spreading as a mechanism for the progression of autoimmune diseases is presented.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9781402000379\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9789401038775\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Hardcover - 9781402000379","offer_id":50726417222,"sku":"9781402000379","price":160.49,"currency_code":"EUR","in_stock":true},{"title":"Softcover - 9789401038775","offer_id":40566823682141,"sku":"9789401038775","price":160.49,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/f9619e8b-e917-444a-87ea-1916867f3394.jpg?v=1746163833","url":"https:\/\/shop.autorenwelt.de\/products\/autoimmunity-von-andrzej-gorski-hubert-krotkiewski-michal-zimecki-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}