{"product_id":"attenuating-macrophage-m2-polarization-through-cox-2-inhibition-cox-2-inhibitors-as-anti-breast-cancer-modality-von-nem-kumar-jain","title":"Attenuating Macrophage M2 Polarization through COX-2 Inhibition","description":"\u003cp\u003eM2-polarized macrophages are well known for their pro-tumor functions. Owing to their established role in potentiating tumor-neovasculogenesis and metastasis, TAMs have emerged as promising target for anti-cancer immunotherapy. . Hindering macrophage polarization towards a pro-tumor M2 phenotype, or better still reprogramming the M2 like TAMs towards M1 subtype is being considered a beneficial anti-cancer strategy. Furthermore, sizeable body of data indicates for participation of cyclooxygenase-2 (COX-2) in macrophage polarization. Concordantly, inhibition of COX-2 is associated with impaired macrophage polarization. Prompted by this in the current study we decided to explore if inhibition of COX-2 activity via chemical inhibitors may prevent hypoxic cancer cell induced M2-polarization of macrophages. We observed that treatment with Etoricoxib and Flunixin meglumine, established selective and non-selective inhibitors of COX-2 respectively, markedly inhibited hypoxic cancer cell induced of M2-polarization of macrophages thereby indicating for usage of COX-2 inhibition as possible anti-cancer treatment modality.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786200094209\"\u003e\u003ch3\u003eCOX-2 Inhibitors as Anti-Breast cancer modality\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786200094209","offer_id":39455298715741,"sku":"9786200094209","price":39.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/47f86b91-a3c3-4f3c-a6d0-5a84e1a616c5.jpg?v=1769925692","url":"https:\/\/shop.autorenwelt.de\/products\/attenuating-macrophage-m2-polarization-through-cox-2-inhibition-cox-2-inhibitors-as-anti-breast-cancer-modality-von-nem-kumar-jain","provider":"Autorenwelt Shop","version":"1.0","type":"link"}