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Drug discovery is a complex and interdisciplinary research, often with conflicting goals and a complex large data used for the development of a balanced clinical candidate. Written from the perspective of drug discovery, it is a practical guide for the analyst and ADME scientists and advanced students in this field. Separate chapters discuss each important aspect, covering the fundamental concepts of separation science, mass spectrometry and pharmacokinetic (PK) studies discussed with minimum mathematical equations. The present book provides in-hand solutions for offline and online sample extraction methods, column switching techniques, chiral separations and validation of the optimized methods as per the standard protocol and FDA guidelines. With practical details obtained in analytical laboratory...synthesis of drug metabolites and related substances, their characterization, separation, validation and applications in PK studies, book provides a successful approach to design, planning, execution and interpretation of research studies. This book will serve as a practical reference in regular use for researchers and scientist interested in drug discovery.