{"product_id":"application-and-synthesis-of-small-quinoline-derivatives-von-dhaval-b-patel","title":"Application and Synthesis of Small Quinoline Derivatives","description":"\u003cp\u003eIn this book, we have established a green and highly efficient one-pot three component microwave irradiation protocol for the synthesis of various quinoline-4-carboxylic acidscatalyzed by p-TSA. The p-TSA catalyst was easily commercially available and non-hazardous. There are many features of this protocol including high yield of products with high purity as well as lower reaction time compared to conventional methods, a simple work-up processand avoidance of the use of hazardous organic solvents.A simple work-up procedure make the present method a valuable contribution in agreement with green chemistry principles. We have synthesized compounds 4a-4p and tested their biological activity. Molecular docking study was suggested that synthesized compounds were fit into the active site of protein and predict best mechanism of in-silico side. Best dock compound 4c was selected for the molecular dynamics.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786205521984\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786205521984","offer_id":46653909729605,"sku":"9786205521984","price":50.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/a375878c-2775-4177-ac9d-e85a3d0766ad.jpg?v=1759298438","url":"https:\/\/shop.autorenwelt.de\/products\/application-and-synthesis-of-small-quinoline-derivatives-von-dhaval-b-patel","provider":"Autorenwelt Shop","version":"1.0","type":"link"}