{"product_id":"aporphines-mdma-antagonists-and-ache-inhibitors-von-stevan-pecic","title":"Aporphines - MDMA Antagonists and AChE Inhibitors","description":"\u003cp\u003eMDMA is a psychoactive drug which is thought to act via stimulation of secretion as well as inhibition of re-uptake of large amounts of serotonin, noradrenaline and dopamine in the brain.  MDMA also acts directly on a number of receptors, including 5-HT2A receptors.  There is considerable evidence that 5-HT2A antagonists can modulate behavioral and physiological effects of MDMA in animals.    Nantenine an aporphine alkaloid ex Nandina domestica has been reported to block and reverse a range of behavioral and physiological effects of MDMA in mice. In this book is shown synthesis and design of a library of novel analogs in order to investigate the structural requirements for nantenine¿s 5-HT2A activity. To elucidate possible binding modes of these compounds and to determine the correlation with our binding data, we built a 5-HT2A homology model based on a bovine rhodopsin template and then performed docking\/scoring experiments.   In the second part of the book, nantenine as well as a number of flexible analogs were evaluated for acetylcholinesterase (AChE) inhibitory activity in a microplate spectrophotometric assays based on Ellman¿s method.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783847344919\"\u003e\u003ch3\u003eSynthesis and Evaluation\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783847344919","offer_id":39482524041309,"sku":"9783847344919","price":59.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/34324a15-0dd0-4953-ab33-824cf5ef741a.jpg?v=1770450149","url":"https:\/\/shop.autorenwelt.de\/products\/aporphines-mdma-antagonists-and-ache-inhibitors-von-stevan-pecic","provider":"Autorenwelt Shop","version":"1.0","type":"link"}