Antimicrobial Activity of 1,3,4-oxadiazole analogues: SAR among 1,3,4-oxadiazoles

Antimicrobial Activity of 1,3,4-oxadiazole analogues: SAR among 1,3,4-oxadiazoles

von Harish Rajak
Taschenbuch - 9783848498727
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Beschreibung

A novel series of 1,3,4-oxadiazole analogues were synthesized for their antimicrobial activities using disk diffusion and agar streak dilution method. The synthesized compounds were tested for their in vitro antimicrobial activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, the Gram negative bacteria Proteus mirabilis and Pseudomonas aeruginosa, the fungal strain Aspergillus niger and the yeast like pathogenic fungus Candida albicans. All the compounds were found to possess a broad spectrum of antimicrobial activities. Synthesized oxadiazole analogues exhibited more pronounced inhibitory activity against Gram-positive bacteria than Gram-negative bacteria. Antifungal properties of the oxadiazole analogues were found to be weaker when compared to their antibacterial activity. The efforts were also made to establish structure activity relationships among synthesized compounds.

Details

Verlag LAP Lambert Academic Publishing
Ersterscheinung April 2012
Maße 220 mm x 150 mm x 14 mm
Gewicht 374 Gramm
Format Taschenbuch
ISBN-13 9783848498727
Auflage Nicht bekannt
Seiten 240

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