{"product_id":"antigens-from-leishmania-amastigotes-protect-human-against-leishmania-von-jose-odaly","title":"Antigens from Leishmania Amastigotes, protect Human against Leishmania","description":"\u003cp\u003eIn the endemic ¿Valle Arribä neighborhood, located in Caracas, Venezuela, with leishmaniasis morbidity 24.76 o\/oo, an amastigotes vaccine with four Leishmania species was applied for protection against leishmaniasis in 3,191 people with a follow up of three years and also in hyperendemic ¿El Ingenio¿ with morbidity of 164.04 o\/oo. The vaccine contains 8-10 proteins after treatment amastigotes with TLCK and NP40. Before the vaccine both vaccinated and control groups had 24% of positive volunteers to Delayed Type Hypersensitivity intradermic reaction with vaccine antigens. One month after three vaccines, 95.67% of vaccinees previously DTH negative converted to a positive DTH. The morbidity rate was 7.94 o\/oo in the vaccinated group, and 56.17 in the control-unvaccinated group, an incidence 7.07 times bigger after three years of the field trial. In ¿La Plantä hyperendemic zone 41.78% were DTH positive before vaccination, with 122 cases from 1972-1994 and highest morbidity (205.23 o\/oo) in 0-5 years old, which points out to intra-domiciliary transmission of the disease . ELISA and immunoblottings were equal before and after vaccination, the vaccine induced cellular immunity.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783330083110\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783330083110","offer_id":39426893709405,"sku":"9783330083110","price":49.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/8f318b15-3461-4a01-a4e3-958217430c14.jpg?v=1776312966","url":"https:\/\/shop.autorenwelt.de\/products\/antigens-from-leishmania-amastigotes-protect-human-against-leishmania-von-jose-odaly","provider":"Autorenwelt Shop","version":"1.0","type":"link"}