{"product_id":"anti-malaria-drugs-and-plasmodium-falciparum-gametocytes-prevalence-von-eltayeb-ali","title":"Anti-malaria Drugs and Plasmodium falciparum Gametocytes Prevalence","description":"\u003cp\u003eWe monitored post-treatment Plasmodium falciparum among patients treated with chloroquine (CQ) and Fansidar (SP) in a village in eastern Sudan. Parasites were examined on day0, day7, day14 and day21 during the transmission season. A further sample was taken 2 months later (day80) at the start of the dry season. Asexual forms and gametocytes were detected by microscopy,and reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect expression of gametocyte-specific proteins pfs25 and pfg377. Microscopic gametocytes increased significantly following CQ and SP treatment, reaching a maximum between days7 and14. When measured by RT-PCR, however, there was no significant difference in gametocyte rate between day0 and days7 or 14. RT-PCR gametocyte rates dropped dramatically by day80 post treatment but were still 33% and 8% in the CQ- and SP-treated groups at this time. Drug resistance alleles to CQ (pfcrt,and pfmdr1) and to SP (dhfr) were seen at a high frequency at the beginning of treatment and increased further through time following both drug treatments. Infections with drug-resistant parasites tended to have higher gametocyte prevalence than drug-sensitive infections\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659357312\"\u003e\u003ch3\u003eGametocyte Prevalence and Drug Resistance following treatment of Uncomplicated Plasmodium falciparum Malaria\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783659357312","offer_id":39485409591389,"sku":"9783659357312","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/942d109d-3f74-46f3-96eb-edb9fa6242bd.jpg?v=1759900832","url":"https:\/\/shop.autorenwelt.de\/products\/anti-malaria-drugs-and-plasmodium-falciparum-gametocytes-prevalence-von-eltayeb-ali","provider":"Autorenwelt Shop","version":"1.0","type":"link"}