{"product_id":"anca-associated-vasculitides-immunological-and-clinical-aspects-von-wolfgang-l-gross-hrsg","title":"ANCA-Associated Vasculitides","description":"\u003cp\u003eWEGENER'S GRANULOMATOSIS \u0026amp; ANCA-ASSOCIATED DISEASES: THE STORY CONTINUES The disease now designated as Wegener's granulomatosis (WG) was first described in 1931 by Heinz Klinger, who considered it to be a special form of polyarteritis nodosa. Klinger's friend, Friedrich Wegener, expanded on the first observations and interpreted the pathological and clinical fmdings to represent a distinct disease entity (Wegener, 1939). He described this entity as a \"peculiar rhinogenous granulomatosis with a unique participation of the arterial system and the kidneys\". Later, Godman and Churg (1954) established the classical diagnostic criteria (the \"WG triad\"): granuloma, vasculitis, and glomerulonephritis. In 1958 Walton pointed out the poor prognosis of WG based on a small number of published cases (mean survival time: 5 months). In 1966 Carrington and Liebow reported \"limited forms\" of WG with a defmitely more favorable prognosis. Since then positive results have been reported with cyclophosphamide therapy. In addition, a retrospective study of combined low-dose cyclophosphamide and prednisolone in 85 WG patients over a period of 21 years found a similarly encouraging outcome. The·latter experience led to the current \"standard\" treatment protocol (FAUCI et al. , 1973 and 1983). More recently, strong evidence has emerged that some of the morbidity and mortality ofWG - and other types of systemic vasculitis - may be a consequence of this treatment (Hoffman et al. , 1992).\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9780306445736\"\u003e\u003ch3\u003eImmunological and Clinical Aspects\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9781475791846\"\u003e\u003ch3\u003eImmunological and Clinical Aspects\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Hardcover - 9780306445736","offer_id":50726810758,"sku":"9780306445736","price":320.99,"currency_code":"EUR","in_stock":true},{"title":"Softcover - 9781475791846","offer_id":39414961340509,"sku":"9781475791846","price":320.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/574e91fa-9278-41fc-adc2-2d8a1e17a5cd.jpg?v=1777263919","url":"https:\/\/shop.autorenwelt.de\/products\/anca-associated-vasculitides-immunological-and-clinical-aspects-von-wolfgang-l-gross-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}