{"product_id":"amidin-synthesis-and-investigation-of-its-anti-diabetic-properties-von-azhar-hajri","title":"AMIDIN: Synthesis and investigation of its anti-diabetic properties","description":"\u003cp\u003eIn the present study, we synthesized N-Ethyl-N¿-(4H-1,2,4-triazol-3-yl) ethanamidine. We subsequently tried to test the action of amidine 2 at different doses ranging from 0.1mg to 0.4mg\/kg bw on glucose-induced hyperglycemia in mice by comparing this effect with that of MetF a standard molecule. Starch significantly reduced blood glucose levels in normal and subacute hyperglycemic mice by glucose administration. In this context, we showed an increase in lipid peroxidation and a decrease in thiol groups.These alterations are accompanied by a reduction in antioxidant power. This protective action of the tested molecule would be essentially linked to its antioxidant activity and its action of improvement of the antioxidant enzymes. Starch induced a significant decrease of the concentration of glucose in blood and protected against the loss of body weight after a duration of treatment 30 days in mice made diabetic by alloxane, a very important diabetogenic chemical product\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786205256800\"\u003e\u003ch3\u003eSynthesized from N-Ethyl-N¿-(4H-1,2,4-triazol-3-yl)ethanamidine\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786205256800","offer_id":40619933892701,"sku":"9786205256800","price":54.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b81addf8-aa18-41c9-a199-5ade6bfc4522.jpg?v=1759383746","url":"https:\/\/shop.autorenwelt.de\/products\/amidin-synthesis-and-investigation-of-its-anti-diabetic-properties-von-azhar-hajri","provider":"Autorenwelt Shop","version":"1.0","type":"link"}