{"product_id":"alternative-methods-for-obtaining-of-cherylline-derivatives-von-stanimir-manolov-iliyan-ivanov","title":"Alternative methods for obtaining of cherylline derivatives","description":"\u003cp\u003eIn this book are presented the results from research on alternative approaches towards the synthesis of 4- aryl-l,2,3,4-tetrhydroisoquinolines as synthetic analogues of the alkaloid cherylline. Optimal conditions for the synthesis of the required 2,2-disubstituted ethylamine precursors are found. The Schotten- Baumann method for amide synthesis is then successfully applied and the synthesized amides are used in an intramolecular ¿-amidoalkylation reaction to obtain 4-substituted 1,2,3,4-tetrahydroisoquinolines. An eco-friendly procedure utilizing PPA\/SiO2 catalyst for the intramolecular ¿ -amidoalkylation is developed. Microwave-assisted variant of this eco-friendly procedure is also successfully developed. By the Bischler-Napieralski method are synthesized five new 1,4- disubstituted-l,2,3,4-tetrahydroisoquinolines. These are potential inhibitors of DHODH. It is found that the reduction of 1,4-disubstituted 3,4-dihydroisoquinolines leads to formation of diastereoisomers. The diastereoisomers are successfully separated by preparative column chromatography and 2:1 (cis:trans) ratio is determined. This ratio is not affected by the temperature at which the reaction is carried out.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786202078573\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786202078573","offer_id":39465437069405,"sku":"9786202078573","price":23.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/d2439bd0-8e3f-4c99-87f5-cc2b0d4c0dad.jpg?v=1773817665","url":"https:\/\/shop.autorenwelt.de\/products\/alternative-methods-for-obtaining-of-cherylline-derivatives-von-stanimir-manolov-iliyan-ivanov","provider":"Autorenwelt Shop","version":"1.0","type":"link"}