{"product_id":"acetylcholine-and-posttraumatic-stress-disorder-von-elizabeth-goble","title":"Acetylcholine and Posttraumatic Stress Disorder","description":"\u003cp\u003ePosttraumatic Stress Disorder (PTSD) is a psychiatric condition that can develop following  exposure to a traumatic event involving actual or threatened death or serious injury.  Responses include intense fear, helplessness or horror. Symptoms are characterised into clusters,  described as re-experiencing, avoidance, and arousal. These symptoms, which are also  evident in other conditions, have been associated with dysfunctions in the central acetylcholinergic  system. Benefits from administering acetylcholinesterase inhibitors (AChEI) to  people suffering these symptoms have been demonstrated. Donepezil hydrochloride, a reversible  inhibitor of the enzyme acetylcholinesterase, is used in the treatment of conditions  with difficulties in cognitive function, but has not been used in PTSD.  The aim of this thesis was to determine (1) whether there was a difference in the ACh  system in people with PTSD and (2) whether administration of an AChEI would change  the symtomatology. IDEX (I123 iododexetimide) has been useful in imaging muscarinic-ACh receptors using  Single Photon Emission Computerised Tomography (SPECT) and was utilised to investigate  whether cholinergic activity in PTSD is altered.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783846519394\"\u003e\u003ch3\u003eDoctoral Dissertation\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783846519394","offer_id":39493521604701,"sku":"9783846519394","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/1be9d09d-4af8-4d21-92b6-a1579d1702fb.jpg?v=1759211279","url":"https:\/\/shop.autorenwelt.de\/products\/acetylcholine-and-posttraumatic-stress-disorder-von-elizabeth-goble","provider":"Autorenwelt Shop","version":"1.0","type":"link"}