{"product_id":"a-structure-based-drug-design-study-on-vegfr-2-inhibitors-von-ajay-babu-p-viswa-teja-colluru-und-naishitha-anaparthy","title":"A STRUCTURE BASED DRUG DESIGN STUDY ON VEGFR-2 INHIBITORS","description":"\u003cp\u003eVEGF (Vascular Endothelial Growth Factor) is a potent  angiogenic signal implicated with a key role in  several pathological processes, including tumour  vascularization, angiogenesis, and endothelial cell  growth. The members of VEGF family bind  to tyrosine  kinase receptors on the cell surface to initiate a  signalling cascade. VEGFR-2 is one such Receptor  Tyrosine Kinase(RTK) that is found to  mediate a majority of the cellular responses to VEGF. A structure based drug design study was performed on  VEGFR-2 inhibitors based on the article ¿Hetaryl  imidazoles: A novel dual inhibitors of VEGF receptors  1 and 2¿. The target protein was retrieved from the  Protein Data Bank (I.D. 2OH4), based on the  Ramachandran plot. The structures of reported  inhibitors were obtained in 3-D format using standard  software packages. These 3-D analogues were docked to  the protein of choice using Molegro Virtual Docker.  Based on a correlation between experimentally  obtained log IC50 values and the results of the  docking study, direct drug design was carried out.  Novel inhibitors with significantly higher moldock  scores were obtained with simple modifications to the  original structure.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844319897\"\u003e\u003ch3\u003eExploiting Molecular Docking and In-Silico Validation\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844319897","offer_id":39495939588189,"sku":"9783844319897","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/d0726b53-db4c-41d1-aa5f-76177e988c49.jpg?v=1752643838","url":"https:\/\/shop.autorenwelt.de\/products\/a-structure-based-drug-design-study-on-vegfr-2-inhibitors-von-ajay-babu-p-viswa-teja-colluru-und-naishitha-anaparthy","provider":"Autorenwelt Shop","version":"1.0","type":"link"}