{"product_id":"a-biochemical-study-of-foxm1-and-tp53-genes-in-breast-cancer-patients-von-dhafer-alkoofee","title":"A Biochemical Study of FOXM1 and TP53 Genes in Breast Cancer Patients","description":"\u003cp\u003eBackground: Breast cancer is a malignant tumor arising from the terminal duct lobular unit of the breast tissues. It is most prevalent malignancy in women and its incidence is increasing, approximately equals to 5-10%.Forkhead box M1 (FOXM1) is a transcription factor associates with proliferation signals and over-expressed in majority of human cancer involved breast. TP53 gene negatively regulates FOXM1 expression and therefore inactivation of TP53 in tumors could partially illustrate the phenomenon of FOXM1 over-expression in human cancers. Objectives: The main objective of the current study is to analyze FOXM1 and TP53 gene expressions levels in formalin fixed paraffin embedded tissues of breast cancer specimens.Subjects and Methods: One hundred formalin fixed paraffin embedded (FFPE) tissue samples of malignant breast tumors as well as 100 FFPE samples of normal breast tissues were investigated. Ages of patients (Mean ±SD) were 48.4 ± 10.90 year with a minimum to maximum of 20 -75 years. Total mRNA was extracted from FFPE blocks by using a specific kit.FOXM1 and TP53 gene expressions were estimated quantitatively by real time PCR.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659709616\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659709616","offer_id":39449276579933,"sku":"9783659709616","price":71.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/9009236f-eeae-44bf-a6c3-dc1cd715d259.jpg?v=1774935632","url":"https:\/\/shop.autorenwelt.de\/products\/a-biochemical-study-of-foxm1-and-tp53-genes-in-breast-cancer-patients-von-dhafer-alkoofee","provider":"Autorenwelt Shop","version":"1.0","type":"link"}