1,3-Pyrimidine Derivatives: Synthesis and Antimicrobial Activity

1,3-Pyrimidine Derivatives: Synthesis and Antimicrobial Activity


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von Anoop Kumar Pathak, Viney Chawla, Shailendra K. Saraf

Beschreibung

There has been growing menace of antibiotic resistance in recent past owing to a number of reasons such as self medication and non-compliance on parts of patients with regard to complete dosage regimen. Medicinal chemists are hard pressed to bring about new molecules to cater to this need. 1,3-pyrimidine derivatives have been explored by a number of scientists worldwide and such these derivatives have emerged potential lead molecules for development of newer antimicrobial moieties. The present work reports the syntheses and evaluation of some 2-(6'-fluorobenzothiazol-2'-ylamino)-4,6-(disubstituted thiouriedo) -1,3-pyrimidine derivatives. Some of the synthesized derivatives showed excellent activity against Gram +ve bacteria Staphyllococcus aureus, Bacillus subtilis, and Gram -ve bacteria Escherichia coli and Pseudomonas aeruginosa. The contents of this book must make an excellent read for those interested in antibiotic research and allied interests.


Tags: Chemie, Organische Chemie


Taschenbuch - 9783848488353
Verlag: LAP Lambert Academic Publishing
Ersterscheinung: April 2012
ISBN-13: 9783848488353
Größe: 220 mm x 150 mm x 7 mm
Gewicht: 189 Gramm
116 Seiten
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