There has been growing menace of antibiotic resistance in recent past owing to a number of reasons such as self medication and non-compliance on parts of patients with regard to complete dosage regimen. Medicinal chemists are hard pressed to bring about new molecules to cater to this need. 1,3-pyrimidine derivatives have been explored by a number of scientists worldwide and such these derivatives have emerged potential lead molecules for development of newer antimicrobial moieties. The present work reports the syntheses and evaluation of some 2-(6'-fluorobenzothiazol-2'-ylamino)-4,6-(disubstituted thiouriedo) -1,3-pyrimidine derivatives. Some of the synthesized derivatives showed excellent activity against Gram +ve bacteria Staphyllococcus aureus, Bacillus subtilis, and Gram -ve bacteria Escherichia coli and Pseudomonas aeruginosa. The contents of this book must make an excellent read for those interested in antibiotic research and allied interests.
Tags: Chemie, Organische Chemie
Taschenbuch - 9783848488353 Verlag: LAP Lambert Academic Publishing Ersterscheinung: April 2012 ISBN-13: 9783848488353 Größe: 220 mm x 150 mm x 7 mm Gewicht: 189 Gramm 116 Seiten Versandfertig in 3-5 Tagen.