1,3-Pyrimidine Derivatives: Synthesis and Antimicrobial Activity

1,3-Pyrimidine Derivatives: Synthesis and Antimicrobial Activity

von Anoop Kumar Pathak, Shailendra K. Saraf, Viney Chawla
Taschenbuch - 9783848488353
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Beschreibung

There has been growing menace of antibiotic resistance in recent past owing to a number of reasons such as self medication and non-compliance on parts of patients with regard to complete dosage regimen. Medicinal chemists are hard pressed to bring about new molecules to cater to this need. 1,3-pyrimidine derivatives have been explored by a number of scientists worldwide and such these derivatives have emerged potential lead molecules for development of newer antimicrobial moieties. The present work reports the syntheses and evaluation of some 2-(6'-fluorobenzothiazol-2'-ylamino)-4,6-(disubstituted thiouriedo) -1,3-pyrimidine derivatives. Some of the synthesized derivatives showed excellent activity against Gram +ve bacteria Staphyllococcus aureus, Bacillus subtilis, and Gram -ve bacteria Escherichia coli and Pseudomonas aeruginosa. The contents of this book must make an excellent read for those interested in antibiotic research and allied interests.

Details

Verlag LAP Lambert Academic Publishing
Ersterscheinung April 2012
Maße 220 mm x 150 mm x 7 mm
Gewicht 189 Gramm
Format Taschenbuch
ISBN-13 9783848488353
Auflage Nicht bekannt
Seiten 116

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