{"product_id":"tissue-engineered-scaffolds-for-nerve-regeneration-von-mahesh-chandra-dodla","title":"Tissue Engineered Scaffolds for Nerve Regeneration","description":"\u003cp\u003eRevision with unchanged content. Injuries to the nervous system result in severe loss of motor and sensory  functions. Nerve autografts are widely used clinically to repair injured nerves.  However, nerve grafts have many limitations, including availability and loss of  function at donor site. To overcome these problems, we have used a tissue  engineering approach to design three-dimensional (3D) scaffolds containing  laminin-1 (LN-1) and nerve growth factor (NGF). After nerve injury and during  embryonic development, several extra-cellular matrix molecules and  neurotrophic factors contribute to nerve regeneration and repair. Our 3D  agarose hydrogel scaffolds with gradients of LN-1 and NGF are designed to  mimic these in vivo conditions to promote nerve regeneration in rats. These  scaffolds have shown to promote nerve regeneration comparable to using  nerve autografts in rats.  This book, therefore, provides a novel technique of nerve scaffold preparation  for greater success in nerve regeneration. Scientists and students of neural  engineering could use this technique to design novel scaffolds. Optimization  of this technique could result in a viable alternative to using nerve grafts for  nerve regeneration.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783639433883\"\u003e\u003ch3\u003eGradients of Molecules Enhance  Nerve Regeneration\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783639433883","offer_id":39489898807389,"sku":"9783639433883","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/f2fc97f3-d6f4-475a-b505-a1f6d933bf24.jpg?v=1772865985","url":"https:\/\/shop.autorenwelt.de\/en\/products\/tissue-engineered-scaffolds-for-nerve-regeneration-von-mahesh-chandra-dodla","provider":"Autorenwelt Shop","version":"1.0","type":"link"}