{"product_id":"tetracyclines-and-macromolecule-von-mateen-khan","title":"TETRACYCLINES AND MACROMOLECULE","description":"\u003cp\u003eTetracyclines are well known broad spectrum  antibiotics, bind with macromolecules (serum albumin  and DNA). The higher binding affinity of  tetracyclines for macromolecules in the body is  implicated in drug stability and potency with a  potential risk of macromolecular damage due to  intracellular accumulation of tetracyclines. Photo- oxidation of TCs produces reactive oxygen species.  Reactive oxygen species not only damage the protein  but also induce strand breaks in DNA. Direct binding  of tetracyclines with DNA, inducing the  conformational changes, and the concomitant  reduction of Cu(II), involving the formation of free  radicals contribute for the strand breakage. There  by indicating the essential role of hydroxyl  radicals in the DNA breakage in addition to the  methylation at N-3 and N-7 position of purine (A\u0026amp;G)  which resulted mismatched of the base pairs. Thus in  addition to the formation of strand breaks, the  methylation of DNA bases by tetracyclines is also  potentially mutagenic.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844393224\"\u003e\u003ch3\u003eBinding and Damaging properties of Tetracyclines to albumin and DNA\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844393224","offer_id":39470087045213,"sku":"9783844393224","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b4f465af-7044-4a51-9a48-369f89e6e82c.jpg?v=1757825505","url":"https:\/\/shop.autorenwelt.de\/en\/products\/tetracyclines-and-macromolecule-von-mateen-khan","provider":"Autorenwelt Shop","version":"1.0","type":"link"}