{"product_id":"strukturnye-izmeneniq-dnk-i-rnk-von-heidar-ali-tajmir-riahi","title":"Strukturnye izmeneniq DNK i RNK","description":"\u003cp\u003eV nastoqschee wremq wse bol'she priznaetsq wazhnaq rol' antioxidantnyh katehinow (polifenolow) chaq w otnoshenii zdorow'q cheloweka i profilaktiki raka. V ätoj knige my rassmatriwaem wliqnie chajnyh katehinow na struktury i dinamiku DNK i RNK. Byli proanalizirowany äffektiwnost' kon#ügacii i swqzywaniq chajnyh katehinow (+)-katehin (C), (-)-äpikatehin gallat (ECG) i (-)-äpigallokatehin gallat (EGCG) s DNK timusa telenka i transfernoj RNK. Termodinamicheskij analiz pokazal, chto katehiny chaq swqzywaüt DNK i tRNK posredstwom gidrofil'nyh i gidrofobnyh wzaimodejstwij s äffektiwnost'ü swqzywaniq 40-60%. Bolee krupnye katehiny obrazuüt bolee stabil'nye addukty DNK i tRNK w porqdke stabil'nosti EGCG\u0026gt;ECG\u0026gt;C. Modelirowanie pokazalo, chto swqzywanie katehina s polinukleotidami proishodit cherez pary osnowanij G-C, A-T i A-U so swobodnymi änergiqmi swqzywaniq ot -4,4 do -4,6 (C), ot -4,5 do -4,7 (EGC) i ot -4,6 do -4,7 kkal\/mol' (EGCG). Swqzywanie polifenolow chaq wyzwalo znachitel'nye izmeneniq w strukturah DNK i tRNK, w to wremq kak biopolimery ostalis' w natiwnyh konformaciqh.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786204245539\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786204245539","offer_id":39530735927389,"sku":"9786204245539","price":19.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b5d97100-76ec-45b2-b46d-284fd7cd9399.jpg?v=1759208025","url":"https:\/\/shop.autorenwelt.de\/en\/products\/strukturnye-izmeneniq-dnk-i-rnk-von-heidar-ali-tajmir-riahi","provider":"Autorenwelt Shop","version":"1.0","type":"link"}