{"product_id":"structural-characterization-of-galectins-and-galectin-related-protein-von-andrea-flores-ibarra","title":"Structural characterization of Galectins and Galectin-Related Protein","description":"\u003cp\u003eGalectins are a family of beta-galactoside-binding proteins located in a wide range of organisms, where they exert functions that can be mediated by carbohydrate-protein and protein-protein interactions. Using a protein engineering approach, galectin-3 constructs were produced and set to perform structural studies, which allowed to ascertain the position of key amino acids in the N-terminal playing fundamental roles in galectin-3 function, like apoptosis and metastasis. On the other hand, a comprehensive genetic mapping of the galectin family identified one particular Galectin-Related Protein located in bone marrow that has a high degree of sequence identity with galectins, sharing their jelly-roll characteristic folding. Interestingly, GRP does not bind beta-galactosides. In order to study in detail the entirety of the galectin family for themes of divergence and recognition within a limited number of proteins, G. gallus GRP was chosen as model. This protein's structural resolution showed the particular hallmarks that hinder beta-galactoside binding.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786139825400\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786139825400","offer_id":39455230066781,"sku":"9786139825400","price":54.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/a9c80b60-a501-4d10-809f-d7bef95c469c.jpg?v=1757744144","url":"https:\/\/shop.autorenwelt.de\/en\/products\/structural-characterization-of-galectins-and-galectin-related-protein-von-andrea-flores-ibarra","provider":"Autorenwelt Shop","version":"1.0","type":"link"}