{"product_id":"statistical-issues-in-the-design-and-analysis-of-clinical-trials-von-yanning-liu","title":"Statistical Issues in the Design and Analysis of Clinical Trials","description":"\u003cp\u003eChapters 1-4 concern statistical methods in designing and analyzing data for survival clinical trials, and predicting trial duration. Chapters 5-7 concern statistical methods in clinical trials with sequential parallel designs, which have been proposed for trials with high placebo response rates which can lead to a higher failure rate in drug development. Utilizing Box and Muller (1958), one of the most popular methods of generating standard normal random variable using two independent uniform (0, 1) deviates, a new method is proposed in Chapter 8 to combine two p-values from two disjoint samples for designing a trial with two stages.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659845543\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659845543","offer_id":39449783140445,"sku":"9783659845543","price":89.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/794fb775-5510-4d02-9e99-b546c677dbfb.jpg?v=1776053715","url":"https:\/\/shop.autorenwelt.de\/en\/products\/statistical-issues-in-the-design-and-analysis-of-clinical-trials-von-yanning-liu","provider":"Autorenwelt Shop","version":"1.0","type":"link"}