{"product_id":"st-andrews-scotland-september-21-24-1982-von-john-a-blair-hrsg","title":"St. Andrews, Scotland, September 21–24, 1982","description":"\u003cp\u003eFrontmatter -- Preface -- ACKNOWLEDGEMENTS -- PARTICIPANTS -- Contents -- The Gowland Hopkins Lecture: Transport of Folate and Pterin Compounds \/ Huennekens, F.M. \/ Suresh, M.R. \/ Grimshaw, C.E. \/ Jacobsen, D.W. \/ Quadros, E.T. \/ Vitols, ¿.S. \/ Henderson, G.B. -- Chemical Aspects (1) -- Scottish International Education Trust Lecture: Synthetic Methods in Pteridine Chemistry: Some Applications to Pteridine Natural Products \/ Taylor, Edward C. -- Synthesis, Chemical and Enzymatic Properties, and Therapeutic Potential of 6,6-Disubstituted Tetrahydroand Quinoid-Dihydro-Pterins \/ Bailey, Steven W. \/ Ayling, June E. -- The Structure of Quinonoid Dihydropterins [2-Amino-7,8(6H)-Dihydropteridin-4-ones] \/ Armarego, Wilfred L.F. \/ Waring, Paul -- Some Simple s-Triazolopteridines \/ Brown, Desmond J. \/ Shinozuka, Kazuo -- Linear Tricyclic Analogs of Pteridines \/ Pendergast, William \/ Chan, Joseph H. -- Reactions of Furazano [3,4-djPyrimidines and their Application to Pteridine Synthesis \/ Boyle, Peter \/ Lockhart, Ronan -- Syntheses of some Blocked 7,8-Dihydropteridines \/ Cameron, Bobert C. \/ Lyall, William J.S. \/ Nicholson, Sidney H. \/ Bobinson, David H. \/ Suckling, Colin J. \/ Wood, Hamish C.S. -- Synthesis of Chiral Reduced Pteridine Coenzymes \/ Doyle, Paul M. \/ Szakolcai, Akos \/ Young, Douglas W. -- Report on Discussions \/ Benkovic, S. J. -- Chemical Aspects (2) -- Reactivity of Pteridines \/ Pfleiderer, Wolfgang \/ Baur, Ralph \/ Bartke, Michael \/ Lut, Hermann -- Synthesis and Antitumor Activity of 10-Deazaminopterins \/ DeGraw, J. I. \/ Brown, V. H. \/ Tagawa, H. \/ Kisliuk, R. L. \/ Gaumont, Y. \/ Sirotnak, F. M. -- Synthesis and Biological Activity of 5-Deazafolic Acid and 5-Deazaaminopterin \/ Taylor, Edward C. \/ Tseng, Chi-Ping \/ Harrington, Peter J. \/ Beardsley, G. Peter \/ Rosowsky, Andrew \/ Wick, Michael -- The Nor-Analogues of Folic Acid \/ Nair, M.G. \/ Rozmyslovicz, Mary K. \/ Kisliuk, R.L. \/ Gaumont, Y. \/ Sirotnak, F.M. -- Report on Discussions \/ Roth, B. -- Neurochemical and Clinical Aspects -- Metabolism of Pteridine Cofactors in Neurochemistry \/ Nichol, Charles A. \/ Viveros, O. Humberto \/ Duch, David S. \/ Abou-Donia, Martha M. \/ Smith, Gary K. -- Pteridines in Cancer and Other Diseases \/ Rokos, Katharina \/ Rokos, Hartmut \/ Frisius, Hildegard \/ Hüfner, Michael -- Dihydropteridine Reductase Activity in Human Breast Cancer. Studies of 580 Cases and Correlations with Hormone Receptors and Cellular Typing \/ Dhondt, Jean-Louis \/ Herlin, Christophe \/ Bonneterre, Jacques \/ Vie, M. Claude \/ Lefebvre, Jean \/ Demaille, Alain -- A Critical Appraisal of Methods for the Quantitative Analysis of Tetrahydrobiopterin, Dihydrobiopterin and Biopterin in Human Urine, Serum and CSE \/ Blair, J.A. \/ Whitburn, S.B. \/ Pheasant, ¿.E. \/ Leeming, R.J. \/ Morar, C. \/ Al-Beir, A. -- Inhibition of Pterin Biosynthesis in the Adrenergic Neuroblastoma N1E115 by Tetrahydrobiopterin and Folate \/ Kapatos, Gregory \/ Kaufman, Seymour -- Penetration of Reduced Pterins into Rat Brain: Effect on Biogenic Amine Synthesis \/ Levine, Robert A. \/ Lovenberg, Walter \/ Niederwieser, A. \/ Leimbacher, W. \/ Redweik, U. \/ Staudenmann, W. \/ Curtius, H.-Ch. -- Neopterin Deficiency (GTP Cyclohydrolase I Deficiency), a New Variant of Hyperphenylalaninemia \/ Niederwieser, A. \/ Staudenmann, W. \/ Wang, M. \/ Curtius, H.-Ch. \/ Atarés, M. \/ Cardesa-Garcia, J. -- Folate Pathways in Cells from Fragile X Syndrome Patients and Carriers \/ Erbe, Richard W. \/ Wang, Jin-Chen C. -- Report on Discussions \/ Cotton, R. G. H. -- Enzymology -- The Interaction of Substrates and Inhibitors with Dihydrofolate Reductase \/ Roberts, Gordon C.K. -- Catalytic Site of Dihydrofolate Reductase \/ Blakley, Raymond L. \/ Cocco, Lennie \/ Montgomery, John A. \/ Temple, Carroll \/ Roth, Barbara \/ Daluge, Susan \/ London, Robert E. -- Structure, Function and Affinity Labelling Studies of Dihydrofolate Reductase \/ Freisheim, J.H. \/ Susten, S. S. \/ Delcamp, T. J. \/ Rosowsky, A. \/ Wright, J. E. \/ Kempton, R. J. \/ Blankenship, D. T. \/ Smith, P. L. \/ Kumar, A .A. -- Methylene Tetrahydrofoíate Reductase: Studies in a Human Mutant and Mammalian Liver \/ Lewis, Garry P. \/ Rowe, Peter B. -- Studies on Methylenetetrahydrofolate Reductase from Pig Liver: Catalytic Mechanism and Regulation by Adenosylmethionine \/ Vanoni, Maria A. \/ Daubner, S. Colette \/ Ballou, David P. \/ Matthews, Rowena G. -- Role of Methylenetetrahydrofolic Acid Reductase in Regulation of Folic Acid Metabolism and its Relation to the Methyl Trap Hypothesis \/ Stokstad, E.L.R. \/ Chan, M.M-S. \/ Watson, J.E. -- The Mechanism of Action of the Transformylase Enzymes \/ Smith, Gary K. \/ Mueller, W. Thomas \/ Benkovic, Patricia A. \/ Slieker, Lawrence J. \/ DeBrosse, Charles W. \/ Benkovic, Stephen J. -- Folypolyglutamate Synthesis in Neurospora Crassa \/ Cossins, E.A. \/ Chan, P. Y. -- Report on Discussions \/ Baccanari, D. P. \/ Kuyper, L. F. -- Clinical Aspects: Cancer -- Folates and Cancer Chemotherapy \/ Bertino, J.R. \/ McGuire, J. J. -- Inability to Increase the Mobilisation of Liver Folates During Folate Deficiency Suggesting that this and Other Organs do not act as a Potential Folate Store for Marrow and Other Rapidly Proliferating Cells \/ Scott, J. M. \/ Molloy, A. \/ Smithwick, A. \/ McGing, P. \/ Weir, D. G. -- A High Molecular Weight Nonfunctional Immunoreactive Form of Dihydrofolate Reductase in L1210 Leukaemia Cells \/ Rothenberg, Sheldon \/ Iqbal, M. Perwaiz -- Further Characterization of the Pterdine Binding Variant of Alphas-Acid Glycoprotein, Accumulated in the Blood of Patients with Malignant Diseases \/ ¿ieger, Irmgard \/ Armarego, Wilfred L. F. \/ Fink, Michael -- Structure-Activity Relationships among 5-Substituted Lipophilic Diaminopyrimidine Antineoplastic Antifolates \/ Cody, Vivian \/ DeJarnette, Elaine \/ Zakrzewski, Sigmund F. -- Attempts to Design Inhibitors of Dihydrofolate Reductase Using Interactive Computer Graphics with Real Time Energy Calculations \/ Potterton, E. A. \/ Geddes, A. J. \/ North, A. C. T. -- Control of Methotrexate Polyglutamate Synthesis in Cultured Rat Hepatoma Cells \/ Galivan, John \/ Balinska, Malgorzata -- Differential Effects of Methotrexate or Fluorodeoxyuridine upon Mitochondrial and Cellular Nucleotide Pools \/ Bestwick, Richard K. \/ Moffett, Ginnie L. \/ Spiro, Craig \/ Mathews, Christopher K. -- Report on Discussions \/ Whiteley, J. M. -- Bioorganic Chemistry and Enzymology -- Chemical Mechanisms in the Action of Pteridine Coenzymes \/ Young, Douglas W. -- Irreversible Inactivation of Rat Liver Phenylalanine Hydroxylase by Reaction with (6S)-L-Erythro-Tetrahydrobiopterin \/ Parniak, Michael \/ Kaufman, Seymour -- p-Azidophenylalanine: A Potential Photoaffinity Probe for Rat-Liver Phenylalanine Hydroxylase \/ Webber, Stephanie \/ Whiteley, John M. -- Pyrimidine Models for the Cofactor of Phenylalanine Hydroxylase \/ Jongejan, J. A. \/ Mager, H. I. X. \/ Berends, W. -- Activation of Molecular Oxygen by Tetrahydropterin Monooxygenases \/ Ayling, June E. \/ Bailey, Steven W. -- Mechanistic Studies on Phenylalanine Hydroxylase: Structural Determination of the Tetrahydropterin Intermediates \/ Lazarus, Robert A. \/ DeBrosse, Charles W. \/ Benkovic, Stephen J. -- Properties of Thymidylate Synthase from Streptococcus Faecium \/ Kisliuk, R. L. \/ Rao, ¿. N. \/ Gaumont, Y. \/ Deschenes, R. \/ Vestal, K. \/ Karasik, M. \/ Maley, G. F. \/ Nair, M. G. \/ Baugh, C. M. -- Cloning the Gene for Eukaryotic C1-THF Synthase \/ Stäben, Chuck \/ Rabinowitz, Jesse C. -- Report on Discussions \/ Armarego, W. L. F. -- Biochemistry and Biology -- The Enzymatic Synthesis of the Drosopterins: Identification of a Pyrimidodiazepine as an Intermediate \/ Wiederrecht, Gregory J. \/ Paton, Duncan R. \/ Brown, Gene M. -- The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis \/ Hearl, W. G. \/ Dorsett, D. \/ Jacobson, K. Bruce -- The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis \/ Wächter, H. \/ Fuchs, D. \/ Hausen, ¿. \/ Reibnegger, G. -- The Role of Pteridines in Regulation of Growth \/ Klein Amy, Nancy \/ Miller, Jeffrey B. -- Evidence for a Folate Bound to Rat Hepatic Uroporphyrinogen III Cosynthase and its Role in the Biosynthesis of Heme \/ Piper, W. N. \/ Tse, J. \/ Clement, R. P. \/ Kohashi, M. -- Report on Discussions \/ Boyle, P. H. -- Presented Papers -- Aerobic Oxidation of 5,6,7,8-Tetrahydroneopterin \/ Armarego, Wilfred L. F. \/ Randies, David -- The Conformations of 7,8 (6H)-Dihydropterin Substrates and the Activity of Dihydropteridine Reductase (E.C.1.6.99.10) \/ Armarego, Wilfred L. F. \/ Waring, Paul -- Dihydrofolate Reductase: The Stereochemistry of Inhibitor Selectivity \/ Matthews, D. A. \/ Bolin, J. T. \/ Filman, D. J. \/ Volz, ¿. W. \/ Kraut, J. -- Synthesis of an 8-Deaza Analog of the Intermediate in the Thymidylate Synthetase Reaction (1) \/ Broom, Arthur D. \/ Srinivasan, Ananthachari -- The Synthesis of Analogs of Pteroylglatamyl-y-Phosphate as Potential Inhibitors of Folylpolyglutamate Synthetase \/ Tang, Kuo-Chang \/ Coward, James K. -- Synthesis and Activity of 8,10-Dideazaminopterin \/ DeGraw, J. I. \/ Kelly, L. F. \/ Kisliuk, R. L. \/ Gaumont, Y. \/ Sirotnak, F. M. -- CNDO\/2 Molecular Orbital Calculations on the Antifolate DAMP and Some of its Analogues: Conformational Characteristics \/ Welsh, William J. \/ Mark, James E. \/ Cody, Vivian \/ Zakrzewski, Sigmund F. -- Fluorescent Analogues of Methotrexate as Probes for Folate Antagonist Molecular Receptors \/ Freisheim, J. H. \/ Kumar, A. A. \/ Black, A. M. \/ Anstead, G. M. \/ Kempton, R. J. \/ Susten, S. S. -- Dihydrofolate Reductase Overproduction Identified by Flow Cytometry Using a Fluorescent Methotrexate Analogue \/ Rosowsky, Andre \/ Wright, Joel E. \/ Beardsley, G. Peter \/ Shapiro, Howard M. -- New Syntheses and Transformations of Some Pteridines and Pteridine 3-Oxides \/ Kocevar, Marijan \/ Stanovnik, Branko \/ TiSler, Miha -- Photooxidation of Mercaptopteridines \/ Heckel, Armin \/ Pfleiderer, Wolfgang -- Reactivity of 6,7-Dichloro-1, 3-Dimethyllumazine \/ Abou-Hadeed, Khaled \/ Pfleiderer, Wolfgang -- Synthesis, Reactivity and Properties of 8-Substituted 2-Thio- and 2,4-Dithiolumazines \/ Hübsch, Walter \/ Pfleiderer, Wolfgang -- The Activity of Sulfonamide-Substituted Benzylpyrimidines Against Dihydropteroate Synthase, Dihydrofolate Reductase, and Bacterial Cell Cultures \/ Hyde, Richard M. \/ Paterson, Richard A. \/ Beddell, Christopher R. \/ Champness, John N. \/ Stammers, David K. \/ Baker, Dorothea J. \/ Goodford, Peter J. \/ Kuyper, Lee F. \/ Ferone, Robert \/ Roth, Barbara \/ Elwell, Lynn P. -- Structural Studies of Antifolate Drugs \/ Schwalbe, Carl H. \/ Cody, Vivian -- Isolation and Characterization of a Novel Folate Antagonist \/ Schlingraann, Gerhard \/ Stokstad, E. L. Robert -- Synthesis and Biological Properties of the S-8 Analog of 7,8-Dihydropteridinealcohol \/ Visser, K. \/ Seydel, J. K. -- Synthesis of Dihydrobiopterin from Dihydroneopterin Triphosphate in Rat Tissues and Human Blood Corpuscles: Diagnosis of Atypical Phenylketonuria due to Biopterin Deficiency by Assay of an Enzyme Involved in the Synthesis \/ Akino, Miki \/ Yoshioka, Shin'ichi \/ Masada, Masahiro \/ Inoue, Kayo \/ Yoshida, Takeo \/ Mizokami, Takashi \/ Matsuo, Nobutake -- Stereospecific Enzyme Mediated Syntheses of Tetrahydrofolate Derivatives \/ Bees, Lilias \/ Suckling, Colin J. \/ Talente, Edward \/ Wood, Hamish C. S. -- Immobilization of Dihydrofolate Reductase from Amethopterin Resistant Lactobacillus Casei \/ Ahmed, Faizy \/ Dunlap, R. Bruce -- X-Ray Studies of the Binding of Trimethoprim, Methotrexate, Pyrimethamine and Two Trimethoprim Analogues to Bacterial Dihydrofolate Reductase \/ Baker, D. J. \/ Beddell, C. R. \/ Champness, J. N. \/ Goodford, P. J. \/ Norrington, F. E. \/ Roth, B. \/ Stammers, D. K. -- A New Spectrophotometry Method for the Assessment of Tight Binding Benzyldiaminopyrimidine Inhibitors of Dihydrofolate Reductase \/ Dann, J. G. -- Two Interconverting Conformers of a Drug-Receptor Complex: The Lactobacillus Casei Dihydrofolate Reductase-NADP+ - Trimethoprim Complex \/ Bevan, A. W. \/ Birdsall, B. \/ Roberts, G. C. K. \/ Feeney, J. \/ Gronenborn, A. \/ Clore, G. M. \/ Burgen, A. S. V. -- Multiple Conformations of the Dihydrofolate Reductase- Folate-NADP+ Complex \/ Birdsall, B. \/ Gronenborn, A. \/ Clore, G. M. \/ Hyde, E. I. \/ Roberts, G. C. K. \/ Feeney, J. \/ Burge, A. S. V. -- The Three-Dimensional Structure of Mouse L1210 Dihydrofolate Reductase \/ Stammers, D. K. \/ Champness, J. ¿. \/ Dann, J. G. \/ Beddell, C. R. -- Isolation and Amino Acid Sequence Studies of Dihydrofolate Reductase from Neisseria Gonorrhoeae \/ Stone, D. \/ Paterson, S. J. \/ Tansik, R. \/ Baccanari, D. P. -- Purification of 7,8-Dihydropteroate-Synthetase from E. Coli by Affinity- and Hydrophobic Interaction Chromatography \/ Bartels, Rainer \/ Bock, Lothar -- Isolation and Characterization of an E. Coli Mutant Affected in Dihydrofolate- and Folylpolyglutamate- Synthetase \/ Ferone, R. \/ Singer, S. C. \/ Hanlon, M. H. \/ Roland, S. -- Purification and Properties of 5-Formyltetrahydrofolate Cyclodehydrase from Rabbit Liver \/ Schirch, LaVerne \/ Hopkins, Sam -- Structural Studies on Formyl-Methenyl-Methylene Tetrahydrofolate Synthetase from Rabbit Liver \/ Peterson, Darrell \/ Schirch, LaVerne -- Utilization of Folate Polyglutamate for Growth by Lactobacillus Casei \/ Maclntyre, Mary-Frances \/ Cooper, Bernard A. \/ Lue-Shing, Helena -- Folate and Folate Enzymes as Structural Components of Bacteriophage Particles \/ Kozloff, L. M. \/ Sadewasser, D. \/ Lute, M. -- Studies on the Substrate Specificity of Mammalian Folylpolyglutamate Synthetase \/ McGuire, J. J. \/ Hsieh, P. \/ Bertino, J. R. \/ Coward, J. ¿. -- Properties of Corynebacterium Species Dihydrofolate Synthetase-Folylpolyglutamate Synthetase \/ Shane, Barry -- Purification and Characterization of Folylpolyglutamate Synthetase from Lactobacillus Casei and Hog Liver \/ Bognar, Andrew L. \/ Cichowiez, David J. \/ Shane, Barry -- The Molybdenum Cofactor from Xanthine Oxidase: Quantitative Assay of the Molybdenum Cofactor by Activation of Nitrate Reductase Activity in Extracts of the Nit-1 Mutant of Neurospora crassa \/ Hawkes, Timothy R. \/ Bray, Robert C. -- Structural Studies of Calf Thymus Thymidylate Synthase \/ Dwivedi, Chandra M. \/ Kisliuk, Roy L. \/ Maley, Gladys F. -- A Comparison of the T-Even Phage Induced and Escherichia Coli Thymidylate Synthases \/ Maley, Gladys F. \/ Beifort, Marlene \/ Maley, Frank -- Thermophilicity of Dihydrofolate Reductase and Thymidylate Synthetase from a Thermophilic Microorganism \/ Mandelbaum-Shavit, Frederika \/ Reizer, Jonathan \/ Grossowicz, Nathan -- Chemical Characterization of Two Folate-Binding Proteins from Mitochondria: Dimethylglycine Dehydrogenase and Sarcosine Dehydrogenase \/ Cook, Robert J. \/ Wagner, Conrad -- Allosteric Mung Bean (Vigna radiata) Serine Hydroxylmethyl-Transferase \/ Narasimha Rao, D. \/ Appaji Rao, N. -- Comparative Study of the Eye Colour Mutants of Drosophila Melanogaster: Quantification of the Eye-Pigments and Related Metabolites \/ Ferré, Juan \/ Silva, Francisco \/ Dolores Real, Maria \/ Ménsua, José Luis -- Studies on Sepialumazine, the Characteristic Larval Integument Pigment of the Bombyx Mori Kiuki Mutant \/ Tsusue, Motoo \/ Mazda, Toshio \/ Sakate, Sakae -- Macromolecular Regulation of Sepiapterin and Drosopterin Synthesis in the Purple Mutant of Drosophila \/ Jacobson, K. Bruce \/ Yim, John J. \/ Wobbe, C. R. -- The Hydroxylation of Phenylpropanoids by Euglena gracilis : Role of Pteridines \/ Fink, Rita \/ Paur, Eva \/ Elstner -- Studies with Old Yellow Enzyme, Reconstitution with Lumazine Analogs as Coenzyme \/ Wetzel, GUnter \/ Ghisla, Sandro -- Biosynthesis of Riboflavin \/ Bacher, Adelbert \/ Le Van, Quang \/ Bühler, Matthias \/ Keller, Paul J. \/ Floss, Heinz G. -- Biosynthesis of Riboflavin \/ Nielsen, Peter \/ Bacher, Adelbert -- Metabolism and Function of Pterin Compounds in Seed Germination \/ Kohashi, Masahiro \/ Tornita, Kazuhiro \/ Iwai, Kazuo -- Thymidylate Synthetase During Proliferation and Differentiation of Physarum polycephalum \/ Gröbner, Peter \/ Loidl, Peter -- Influence of Vitamin B12 on Folate Metabolism in Lactobacillus Leichmannii \/ Nair, C. P. P. \/ Noronha, J. M. -- High-Affinity Binding of Folate to a Small and Large Molecular Size Protein from Human Milk \/ Hansen, Steen Ingemann \/ Holm, Jan \/ Lyngbye, J¿rgen -- High-Affinity Folate Binding in Leukocytes from Normal Subjects Displays Positive Cooperativity, and the Affinity Depends on the Protein Concentration \/ Holm, Jan \/ Hansen, Steen Ingemann \/ Lyngbye, J¿rgen -- Characteristics of 5-Methyltetrahydrofolate Binding to the Folate-Binding Protein from Cow's Whey \/ Lyngbye, J¿rgen \/ Hansen, Steen Ingemann \/ Holm, Jan -- Interactions of Folate-Dependent Enzymes of DNA Precursor Metabolism in T4 Phage-Infected Bacteria \/ Allen, J. R. \/ Booth, Joseph W. \/ Goldman, Daniel A. \/ Lasser, Gerald W. \/ Purohit, Sarla \/ Sargent, R. Geoffrey \/ Mathews, Christopher K. -- The Regulation of Biopterin Biosynthesis in the Rat \/ Milstien, S. \/ Kaufman, S. -- Biosynthesis of Tetrahydrobiopterin in Mammalian Tissues by De Novo and Salvage Pathways \/ Nichol, Charles A. \/ Smith, Gary K. \/ Duch, David S. -- Perspectives on Tetrahydrobiopterin Biosynthesis in Mammals \/ Curtius, H.-Ch. \/ Häusermann, M. \/ Heintel, D. \/ Niederwieser, A. \/ Levine, Robert A. -- Human Dihydropteridine Reductase (DHPR) Deficiency \/ Firgaira, Frank A. \/ Cotton, Richard G.H. \/ Danks, David M. -- Coordinate Regulation of Guanosine Triphosphate Cyclohydrolase and Tetrahydrobiopterin in Adrenal Medullary Chromaffin Cells \/ Abou-Donia, M. M. \/ Daniels, A. J. \/ Wilson, S. P. \/ Nichol, C. A. \/ Viveros, O. H. -- Regulation of Adrenocortical Guanosine Triphosphate Cyclohydrolase and Tetrahydrobiopterin in Normal and Spontaneously Hypertensive Rats \/ Abou-Donia, Martha M. \/ Daniels, Alejandro J. \/ Nichol, Charles A. \/ Viveros, O. Humberto -- Inhibition of Brain Sepiapterin Reductase by a Catecholamine and an Indoleamine \/ Katoh, S. \/ Sueoka, T. \/ Yamada, S. -- Mouse Mastocytoma Tryptophan Hydroxylase: Role of Iron and Catalase in the Expression of Enzyme Activity after Activation by Anaerobic Preincubation with Dithiothreitol \/ Hasegawa, Hiroyuki \/ Yanagisawa, Mariko \/ Inoue, Fumio \/ Ichiyama, Arata -- Folic Acid Induced Kindling in Rats: Changes in Brain Amino Acids \/ O'Donnell, R.A. \/ Leach, M.J. \/ Miller, A. A. -- Impaired Pteroylpolyglutamate Synthesis in the Cobalamin-Inactivated Rat \/ Perry, Janet \/ Chanarin, I. \/ Deacon, Rosemary \/ Lumb, M. -- A Radioimmunoassay for Determination of D-Erythro- Neopterin \/ Rokos, Hartmut \/ Rokos, Katharina -- Radioimmunoassay for Neopterin in Body Fluid and Tissues \/ Nagatsu, Toshiharu \/ Sawada, Makoto \/ Yamaguchi, Tokio \/ Sugimoto, Takashi \/ Matsuura, Sadao \/ Akino, Miki \/ Nakazawa, Nobuhiko \/ Ogawa, Hiroshi -- A Specific Antiserum Against Tetrahydrobiopterin: Its Preparation and Application to Immunohistochemistry \/ Matsuura, Sadao \/ Sugimoto, Takashi \/ Nagatsu, Ikuko \/ Yamaguchi, Tokio \/ Nagatsu, Toshiharu -- Speculation on the Mechanism of Therapeutic Action of Tetrahydrobiopterin in Human Disease \/ Levine, Robert A. \/ Lovenberg, Walter \/ Curtius, H.-Ch. \/ Niederwieser, A. -- Correlation of Tetrahydrobiopterin Content and Guanosine Triphosphate Cyclohydrolase Activity in Cells and Tissues \/ Duch, David S. \/ Nichol, Charles A. -- Unconjugated Pteridines in Human Physiological Fluids. Normal and Pathological Profiles \/ Dhondt, J.-L. \/ Bellahsene, Z. \/ Largilliere, C. \/ Bonneterre, J. \/ Vanhille, P. \/ Noel, C. \/ Choteau, P. \/ Farriaux, J. P. -- Biopterin and Phenylalanine Metabolism During Early Liver Regeneration \/ Dhondt, Jean-Louis \/ Kapatos, Gregory \/ Parniak, Michael \/ Wilgus, Harvey \/ Kaufman, Seymour -- GTP-Cyclohydrolase Activities in Rat Liver \/ Dhondt, Jean-Louis \/ Bellahsene, Zina \/ Farriaux, Jean-Pierre \/ Dautrevaux, Michel -- Phenylalanine Hydroxylase Assay Using Biopterin and Synthetic Pteridine \/ Berry, Helen K. \/ Hsieh, Monica -- Dihydropteridine Reductase Levels in Human Normal and Neoplastic Tissues \/ Eggar, C. \/ Barford, P.A. \/ Blair, J. A. \/ Pheasant, A. E. \/ Guest, A. E. \/ Oates, G. D. -- Investigations of Tissue Folates in Normal and Malignant Tissues \/ Pheasant, A. E. \/ Bates, J. \/ Blair, J. A. \/ Nayyir-Mazhir, R. -- Blood Cell Biopterin as an Indicator of Transplanation- Induced Hemopoiesis and Leukemic Cell Proliferation \/ Fink, Michael \/ Ziegler, Irmgard \/ Kölb, Hans-Jochen \/ Bodenberger, Ulrich \/ Wilmanns, Wolfgang -- Assessment of Urinary Neopterin in the Early Diagnosis of Human Allograft Rejection \/ Fuchs, D. \/ Hausen, ¿. \/ Reibnegger, G. \/ Wächter, H. \/ Huber, Ch. \/ Margreiter, R. \/ Spielberger, M. -- Behaviour of Neopterin Levels in Patients with Haematological and Gynaecological Neoplasms \/ Reibnegger, G. \/ Fuchs, D. \/ Hausen, A. \/ Wächter, H. -- Pteridines in Dictyostelium discoideum and Physarum polycephalum \/ Loidl, Peter \/ Fuchs, Dietmar \/ Gröbner, Peter \/ Hausen, Arno \/ Reibnegger, Gilbert \/ Wächter, Helmut \/ Schweiger, Manfred \/ Gerisch, Günther -- Biochemical and Chemotherapy Studies on BW 301U, a Novel Lipophilic 2,4-Diaminopyridopyrimidine Antifolate \/ Duch, David S. \/ Nichol, Charles A. -- Toxicity of a Series of Antifolate Compounds in a Methotrexate-Resistant Celi Line \/ Hamrell, Michael R. -- Interaction of Methotrexate Poly(L-Lysine) with Transformed Hepatic Cells in Culture \/ Whiteley, John M. \/ Galivan, John \/ Balinska, Malgorzata -- A Novel Technique for Producing Folate-Deficient Hepatica Cells \/ Balinska, Malgorzata \/ Samsonoff, William \/ Galivan, John -- Methotrexate Metabolism in Acute Lymphoblastic Leukemia \/ Whitehead, V. Michael \/ Rosenblatt, David S. -- Altered Methotrexate Sensitivity in Human Leukemic K562 Amino Acid Transport Mutant Cells \/ Scanlon, Kevin J. \/ Riegelhaupt, Rona \/ Pallai, Michele \/ Kisthard, Holly \/ Kassan, Sharon \/ Waxman, Samuel -- Methotrexate and Methotrexate Polyglutamates in Erythrocytes After High-Dose Methotrexate \/ Schalhorn, Andreas \/ Sauer, Hansjörg \/ Wilmanns, Wolfgang \/ Stupp-Poutot, Gabriele -- Methotrexate Polyglutamates in Human Fibroblasts: Reversal of Antifolate Cytotoxicity \/ Rosenblatt, David S. \/ Whitehead, V. Michael -- Human Cells Resistant to Methotrexate: Cross Resistance and Collateral Sensitivity to the Nonclassical Antifolates Trimetrexate, Metoprine, Homofolic Acid and CB3717 \/ Diddens, Heyke \/ Niethammer, Dietrich \/ Jackson, Robert C. -- Homology of Two Forms of Dihydrofolate Reductase in Human Leukaemic and L1210 Cells During Expression of Resistance to Methotrexate \/ Lamey, Philip \/ Harding, Nigel \/ Dow, Jocelyn -- Adaptation of Folylpolyglutamates to Folate Deprivation in Mouse Hepatoma Cells \/ Priest, D. G. \/ Doig, M. T. \/ Mangum, M. -- Utilization and Loss of Reduced Folates by Human Fibroblasts in Vitro \/ Hilton, Jack H. \/ Cooper, Bernard A. \/ Rosenblatt, David S. \/ Lue-Shing, Helena -- Factors Affecting Folate Polyglutamate Biosynthesis in Rat Liver \/ Keating, S. \/ Weir, D. G. \/ Scott, J. M. -- Differential Binding of Folates but not Methotrexate (MTX) by Brush Border (BB) and Basal Lateral (BL) Membranes of Rat Renal Cortex \/ Corrocher, Roberto \/ Abramson, R. G. \/ King, F. V. \/ Schreiber, C. \/ Waxman, S. -- Biosynthesis of Folate Derivatives in Ehrlich Ascites Carcinoma Cells Grown in Mice and in some Organs of the Host \/ Sikora, Ewa \/ Grzelakowska-Sztabert, Barbara -- Variability of Thymidylate Synthetase in Ehrlich Carcinoma Cells and its Role in Resistance to 5-Fluorodeoxyuridine \/ Jastreboff, Malgorzata \/ Kfdzierska, Barbara \/ Rode, Wojciech -- One-Carbon Metabolism in Human Lymphocytes \/ Rowe, P. B. \/ McCairns, E. \/ Sauer, D. \/ Craig, G. -- Possible Mechanisms of Folate Catabolism \/ Pheasant, A. E. \/ Blair, J. A. \/ Saleh, A. M. \/ Guest, A. E. \/ Barford, P. A. \/ Choolun, R. \/ Allan, R. N. -- The Intracellular Folate Pool: Studies of Kinetics and Functional Significance \/ Steinberg, Stephen \/ Fonda, Susan \/ Campbell, Caryl L. \/ Hillman, Robert S. -- Intestinal Folate Transport. A pH-Dependent, Carrier- Mediated Process \/ Strum, Williamson B. \/ Said, Hamid M. -- Effects of Folate Depletion on Growth and Survival of Human Cell Line K-562 in Culture \/ Watkins, David \/ Shapiro, Thomas E. \/ Cooper, Bernard A. -- Alterations in Folate Metabolism of the Rat Induced by Acute Ethanol Administration \/ McMartin, Kenneth E. \/ Collins, Timothy D. -- Participation of Pterins in the Control of Lymphocyte Transformation and Lymphoblast Proliferation \/ ¿¡eger, Irmgard \/ Ham, Ulrike \/ Berndt, Jürgen -- The Pterin Component of the Molybdenum Cofactor (Molybdopterin): Relationship to Urothione \/ Johnson, Jean L. \/ Hainline, Bryan E. \/ Rajagopalan, ¿. V. -- Report on Presented Papers \/ Suckling, C. J. \/ Scott, J. M. -- Author Index -- Subject Index -- Backmatter\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783110085600\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Hardcover - 9783110085600","offer_id":50691368454,"sku":"9783110085600","price":309.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/3434e45e-5fca-45fd-8265-5bec3bb17386.jpg?v=1779512239","url":"https:\/\/shop.autorenwelt.de\/en\/products\/st-andrews-scotland-september-21-24-1982-von-john-a-blair-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}