{"product_id":"sildenafil-von-undefined","title":"Sildenafil","description":"\n                                \n                \u003cp\u003e\u003c\/p\u003e\n                                \n                \n                \u003cp\u003eThis drug is a landmark discovery, which consequently has become the definitive therapy for the treatment of erectile dysfunction (ED). Following the major breakthrough in the field of nitric oxide (NO)-physiology and pharmacology leading to sildenafil being marketed, the most current information is presented in this reference book, including ongoing research from several disparate groups about NO as endothelium-derived relaxing factor (EDRF) and also as a neurotransmitter for nerves innervating erectile tissue in mammals.\u003c\/p\u003e\n                                \n                \n                \u003cp\u003eThe development of sildenafil as an oral phosphodiesterase-5 (PDE5) inhibitor drug for the treatment of ED resulted in one of the first products, which made its way successfully from basic NO research to routine clinical therapy.\u003c\/p\u003e\n                                \n                \n                \u003cp\u003eThis volume addresses all fields of sildenafil application in both men and women. In a highly competitive research environment with a critical medical need for drug improvements the reader will learn more about clinical resistance to sildenafil treatment and the modalities to overcome the failure rates. \u003c\/p\u003e\n                                \n                \n                \u003cp\u003eThe individual chapters cover clinical use, pharmacokinetics, pharmacodynamics, biochemistry, and cultural aspects. They are written by leading experts in their respective fields. Therefore, readers – whether professionals in the pharmaceutical industry, physicians treating ED, biochemists, chemists or pharmacologists – will find a detailed and up-to-date knowledge base about current research activities and an excellent overview for further research on this compound class and its cultural impact.\u003c\/p\u003e\n                            \n            \u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783034896313\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783764362553\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783034896313","offer_id":49592163565893,"sku":"9783034896313","price":235.39,"currency_code":"EUR","in_stock":true},{"title":"Hardcover - 9783764362553","offer_id":49592953766213,"sku":"9783764362553","price":235.39,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/3b5a1853-cffd-47dd-bb96-ab12aced36f6.jpg?v=1778910052","url":"https:\/\/shop.autorenwelt.de\/en\/products\/sildenafil-von-undefined","provider":"Autorenwelt Shop","version":"1.0","type":"link"}