{"product_id":"serologic-markers-in-screening-for-coeliac-disease-von-klas-sjoberg","title":"Serologic markers in screening for coeliac disease","description":"\u003cp\u003eBased on serial antibody analysis [gliadin (GA) and  endomysium (EMA)], the prevalence of coeliac disease  (CD) was 6\/1970 (0.30%). In autoimmune chronic  hepatitis 5.4% and in IDDM 2.6% had CD, why  screening for CD could be motivated. IgA-GA  positivity was increased in alcoholic liver disease,  PBC, primary sclerosing cholangitis, chronic  hepatitis, hepatitis C, IDDM, NIDDM, and in  secondary diabetes to 11-24% compared with blood  donors (5%). CD was correlated with HLA-DQ2\/DR3,  while DQ1, DQ7, DR1, DR4 and DR5 were inversely  correlated. 79% of GA-positive but healthy  individuals had DQ1, which would be expected to  confer protection. The findings suggest GA- positivity to be independent of the HLA genotype in  CD. From 848 IDDM patients 16 high titre GA patients  were selected. Chronic thyroiditis, thyroid  peroxidase, factor XIII IgA antibody positivity and  HLA DRB1*13 were correlated with GA-positivity,  while tissue transglutaminase IgG titres were  inversely correlated. A patient with CD and  antibodies against the active site of factor XIII is  described. In 20 patients with EMA no correlation  between tTg and factor XIII was  observed.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843379311\"\u003e\u003ch3\u003eClinical significance and immunogenetic basis\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843379311","offer_id":39497119629405,"sku":"9783843379311","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/594e3aa3-f264-452a-818e-4b600cd5ffbc.jpg?v=1769667909","url":"https:\/\/shop.autorenwelt.de\/en\/products\/serologic-markers-in-screening-for-coeliac-disease-von-klas-sjoberg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}