{"product_id":"rheumatoid-arthritis-and-b-cell-depletion-therapy-relationships-between-expression-of-b-cell-activating-factor-binding-receptors-and-patterns-of-clinical-relapse-von-elena-becerra-inmaculada-de-la-torre-geraldine-cambridge","title":"Rheumatoid arthritis and B cell depletion therapy","description":"\u003cp\u003eRheumatoid arthritis is a chronic systemic inflammatory disease with joint involvement and extra-articular features. B cell depletion therapy based on Rituximab in rheumatoid arthritis was first used at University College London in 1998, describing two patterns of disease relapse after a good response to Rituximab: either occurring coincident with B-cell return (concordant relapse) or ¿delayed¿ occurring months after B-cell return (discordant relapse). B-cell activating factor (BAFF) and its receptors (BARR-receptor, TACI and BCMA) play an esential role in B-cell maturation, homeostasis and survival. The current thesis hypothesises that the two different patterns of relapse after B cell repopulation following Rituximab could be explained by differences in the expression of BAFF and its binding receptors.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786202307437\"\u003e\u003ch3\u003eRelationships between expression of B-cell activating factor binding receptors and patterns of clinical relapse\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786202307437","offer_id":39447671734365,"sku":"9786202307437","price":79.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/935c6a87-d4a6-4156-ab2a-bea49c8c96fe.jpg?v=1758091207","url":"https:\/\/shop.autorenwelt.de\/en\/products\/rheumatoid-arthritis-and-b-cell-depletion-therapy-relationships-between-expression-of-b-cell-activating-factor-binding-receptors-and-patterns-of-clinical-relapse-von-elena-becerra-inmaculada-de-la-torre-geraldine-cambridge","provider":"Autorenwelt Shop","version":"1.0","type":"link"}