{"product_id":"resistance-of-cancer-cells-to-ctl-mediated-immunotherapy-von-benjamin-bonavida-salem-chouaib-hrsg","title":"Resistance of Cancer Cells to CTL-Mediated Immunotherapy","description":"This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783319178066\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Hardcover - 9783319178066","offer_id":40562775392349,"sku":"9783319178066","price":106.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/73461_8fcaafed-3137-4466-83d6-1d2ef5b13718.jpg?v=1784347873","url":"https:\/\/shop.autorenwelt.de\/en\/products\/resistance-of-cancer-cells-to-ctl-mediated-immunotherapy-von-benjamin-bonavida-salem-chouaib-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}