{"product_id":"regulation-of-mhc-class-i-by-dengue-virus-von-shatrah-othman-1","title":"Regulation of   MHC Class I   by Dengue Virus","description":"\u003cp\u003eDespite aggressive efforts in dengue research, the control of dengue diseases and discovery of therapeutics against them await complete elucidation of its complex immune-pathogenesis. Virtually all mammalian cells express surface major histocompatibility complex class I (MHC Class I) molecules which are crucial for immune recognition and MHC-restricted cytolysis as part of the adaptive immune response. In contrast to many viruses that escape this host¿s immune responses by suppressing the MHC Class I pathway, infections by Flaviviruses, such West Nile virus, have been associated with a virus-specific increase of these antigen-presenting molecules. This study presents evidence of MHC Class I gene modulation by dengue virus, hence providing a better understanding of dengue immunopathogenesis that would consequently facilitate the discovery of antiviral therapeutics against dengue.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783848495238\"\u003e\u003ch3\u003eAn Update on Dengue Immunopathogenesis\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783848495238","offer_id":39490003501149,"sku":"9783848495238","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/92790a9d-724a-4f8a-9ba8-49d03f38c7dc.jpg?v=1772866126","url":"https:\/\/shop.autorenwelt.de\/en\/products\/regulation-of-mhc-class-i-by-dengue-virus-von-shatrah-othman-1","provider":"Autorenwelt Shop","version":"1.0","type":"link"}