{"product_id":"regulation-of-b-cell-development-by-antigen-receptors-von-jannek-hauser","title":"Regulation of B cell Development by Antigen Receptors","description":"\u003cp\u003eThe E-protein E2A is well known for its many roles  during B cell development. Antigen receptor  signaling that leads to inhibition of E2A by the  calcium-sensor protein calmodulin (CaM) has  therefore very broad implications. The down- regulation of the surrogate light chains of the  pre-B cell receptor and also the co-receptor CD19  was shown to be through CaM inhibition of E2A.  Furthermore, several components of the Ig  recombination machinery including RAG1 and RAG2 are  down-regulated by this mechanism, and the  recombination complex was shown to include the RAGs,  Pax5 and E2A, which can be directly released from  the Ig heavy chain locus by pre-B cell receptor  signaling through CaM to achieve allelic exclusion.  The tight regulation of the antibody diversification  enzyme AID is also dependent on CaM inhibition of  E2A, and a negative feedback regulation of the pre-B  and B cell receptor proteins and co-receptors and  proteins in signal pathways from the receptor was  also shown to occur through E2A inhibition by CaM.  Plasma cell differentiation is induced by very fast  regulatory events, which are shown to be dependent  on CaM inhibition of E2A.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844325010\"\u003e\u003ch3\u003eStudies on the physiological roles of E2A transcription factors and their inhibition by calmodulin  in B cell development\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844325010","offer_id":39495985627229,"sku":"9783844325010","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/f8429ba9-2d2f-48ef-93a5-f66e1224fa8c.jpg?v=1758345793","url":"https:\/\/shop.autorenwelt.de\/en\/products\/regulation-of-b-cell-development-by-antigen-receptors-von-jannek-hauser","provider":"Autorenwelt Shop","version":"1.0","type":"link"}