{"product_id":"regioselective-synthesis-of-heterocycles-and-their-biological-activity-von-haresh-b-patel","title":"Regioselective synthesis of heterocycles and their biological activity","description":"\u003cp\u003eA simple, efficient solvent free and three-component approach for the synthesis of pyrazole based 1,2,4-triazolo[1,5-a]quinoline derivatives 10(a-l) has been developed by one-pot reaction of 1H-pyrazole-4-carbaldehyde 4(a-d), malononitrile and enaminones 7(a, b) in the presence of pyrrolidine-acetic acid as bifunctional catalyst under solvent free condition. Regioselectivity of reaction performed by different catalyst and higher regioselectivity is achieved by pyrrolidine-acetic acid. This new procedure gives an efficient method to design a fused tricyclic heterocycles containing 1,2,4-triazole analogues. We have using small amount of amphoteric catalyst like ammonium acetate, L-proline and mixture of pyrolidine with acetic acid to obtain 1,4-dihydroquinoline 9j as a byproduct and the salient features of this protocol is higher regioselectivity toward desired products 10(a-l). The structures of the title compounds were confirmed by FT-IR, 1H NMR, 13C NMR and mass spectrometry.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786200303936\"\u003e\u003ch3\u003eRegioselective synthesis of heterocyclic compounds catalyzed via pyrrolidine-acetic acid and their biological activity\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786200303936","offer_id":39924343537757,"sku":"9786200303936","price":39.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/625ad5f3-6fbb-4f06-9110-069bfea3ec0c.jpg?v=1773731249","url":"https:\/\/shop.autorenwelt.de\/en\/products\/regioselective-synthesis-of-heterocycles-and-their-biological-activity-von-haresh-b-patel","provider":"Autorenwelt Shop","version":"1.0","type":"link"}