{"product_id":"redirection-of-th1-and-th2-responses-von-robert-l-coffman-sergio-romagnani-hrsg","title":"Redirection of Th1 and Th2 Responses","description":"\u003cp\u003eIt has been 12 years since the first proposal was made to sub­ divide mouse CD4 I T cell clones into Th I and Th2 subsets, based on their differences in cytokine production, and 7 years since the first clear demonstration of a similar dichotomy among human T cell clones. In the ensuing period, it has been realized that inappropriate development of Th I or Th2 responses are important features of many immunological and infectious dis­ eases. Perhaps the first group of diseases to be understood in terms of preferential Th subset activation were allergic diseases (see PARRONC'HI et aI. , this volume). Several of the major, co­ ordinately regulated, features of allergy, including IgE, eosino­ philia and mastocytosis, were found to be stimulated by the T- specific cytokines I L-4 and IL-5 and inhibited by the Th I cyto­ kine, IFN-. This suggested that the presence and severity of al­ lergic responses reflected the relative numbers of Th I and Th2 cells specific for the offending allergen. Similarly, the very dif­ ferent consequences of protective Th I and nonprotective Th2 responses to a number of intracellular pathogens have been re­ cognized for some time (see TRINCHIERI and SCOTI, and COFF­ MAN et aI. , this volume).\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783662097113\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783662097113","offer_id":39441258807389,"sku":"9783662097113","price":53.49,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/344b4665-6ede-4dd6-807e-843cfe45ce1c.jpg?v=1775711654","url":"https:\/\/shop.autorenwelt.de\/en\/products\/redirection-of-th1-and-th2-responses-von-robert-l-coffman-sergio-romagnani-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}