{"product_id":"platinum-resistance-in-ovarian-cancer-von-michelle-chen","title":"Platinum Resistance in Ovarian Cancer","description":"\u003cp\u003eOvarian cancer is the leading cause of death from gynecologic malignancy in the United Kingdom and the 4th most common cause of cancer mortality in women.  Approximately 1 in 48 women in the UK will develop ovarian cancer in their lifetime.  Surgery followed by chemotherapy involving a platinum-containing compound is the standard treatment for advanced disease. However, despite initial response rates of 70% to platinum-based chemotherapy, chemoresistance frequently develops and is in part responsible for the poor 5-year survival rate of just 30%.  In this book, the role of the AKT pathway is examined in acquired platinum resistance using three isogenically matched cell line pairs derived from ovarian cancer patients, pre- and post-platinum resistant relapse.  Findings here provide evidence for the role of DNA-PKcs in mediating the activation of AKT in response to DNA DSBs caused by the cytotoxic effects of cisplatin, which is observed in platinum-resistant ovarian cancer cell lines, but not platinum-sensitive cell lines.  Targeting DNA-PKcs,  in combination with platinum, presents a novel strategy of reversing platinum resistance and circumventing insulin-related toxicities.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844396287\"\u003e\u003ch3\u003eA Molecular Analysis of the PI3K\/AKT Pathway\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844396287","offer_id":39497137455197,"sku":"9783844396287","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/5724f161-6bde-4142-b844-d45c7647031b.jpg?v=1757911846","url":"https:\/\/shop.autorenwelt.de\/en\/products\/platinum-resistance-in-ovarian-cancer-von-michelle-chen","provider":"Autorenwelt Shop","version":"1.0","type":"link"}