{"product_id":"philosophy-of-cancer-von-marta-bertolaso","title":"Philosophy of Cancer","description":"Since  the 1970s, the origin of cancer is being explored from the point of view of the  Somatic Mutation Theory (SMT), focusing on genetic mutations and clonal  expansion of somatic cells. As cancer research expanded in several directions,  the dominant focus on cells remained steady, but the classes of genes and the  kinds of extra-genetic factors that were shown to have causal relevance in the  onset of cancer multiplied. The wild heterogeneity of cancer-related mutations  and phenotypes, along with the increasing complication of models, led to an  oscillation between the hectic search of ‘the’ few key factors that cause cancer  and the discouragement in face of a seeming ‘endless complexity’. To tame this  complexity, cancer research started to avail itself of the tools that were being  developed by Systems Biology. At the same time, anti-reductionist voices began  claiming that cancer research was stuck in a sterile research paradigm. This  alternative discourse even gave birth toan alternative theory: the Tissue  Organization Field Theory (TOFT). A deeper philosophical analysis shows limits and possibilities of reductionist and anti-reductionist positions and of their  polarization. This book demonstrates that a radical philosophical reflection is  necessary to drive cancer research out of its impasses. At the very least, this  will be a reflection on the assumptions of different kinds of cancer research,  on the implications of what cancer research has been discovering over 40 years  and more, on a view of scientific practice that is most able to make sense of  the cognitive and social conflicts that are seen in the scientific community  (and in its results), and, finally, on the nature of living entities with which  we entertain this fascinating epistemological dance that we call scientific  research. The proposed Dynamic and Relational View of carcinogenesis is a  starting point in all these directions.\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9789402414219\"\u003e\u003ch3\u003eA Dynamic and Relational View\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9789402408638\"\u003e\u003ch3\u003eA Dynamic and Relational View\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9789402414219","offer_id":40150855254109,"sku":"9789402414219","price":117.69,"currency_code":"EUR","in_stock":true},{"title":"Hardcover - 9789402408638","offer_id":40150753575005,"sku":"9789402408638","price":117.69,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/0f9b3be2-53d3-4188-85dd-655dee7428c4.jpg?v=1775713308","url":"https:\/\/shop.autorenwelt.de\/en\/products\/philosophy-of-cancer-von-marta-bertolaso","provider":"Autorenwelt Shop","version":"1.0","type":"link"}