{"product_id":"pectin-hydrogel-copolymers-for-sustained-drug-release-von-yousef-abul-haija","title":"PECTIN HYDROGEL COPOLYMERS FOR SUSTAINED DRUG RELEASE","description":"\u003cp\u003eThe present work describes preparation, optimization  and characterization of pectin grafted poly (vinylpyrrolidone) hydrogels and pectin grafted poly (N-isopropylacrylamide) followed by controllable  theophylline drug release. The gels were prepared in  the presence of N,N''¿methylenebisacrylamide (MBAA)  crosslinker and ceric ammonium nitrate (CAN)  initiator under N2 atmosphere. Hydrogels were  characterized by FTIR, TGA, DSC, XRD and SEM. In  vitro controllable release of theophylline model  drug was studied using different [NVP]\/[MBAA]  ratios, different [NIPAAm]\/[MBAA] ratios and  different polymerization temperatures at two pH  values, namely 5.5 and 7.4. The optimum conditions  for colon-targeted vehicles that could provide the  least theophylline release at pH 5.5, and the most  theophylline release at pH 7.4, for pectin-g-PVP  were as follows: [NVP]\/[MBAA] = 4.33, polymerization  temperature = 10 °C and %G = 62.2. While for pectin- g-PNIPAAm were as follows:  [NIPAAm]\/[MBAA] = 47.34,  polymerization temperature = 10 °C and %G = 50.5.  Such promising hydrogel characteristics may play the  key role in many future drug release implementations.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843369923\"\u003e\u003ch3\u003eSYNTHESES AND CONTROL\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843369923","offer_id":39469984940125,"sku":"9783843369923","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/c281073e-0a8b-48db-80b0-e07b2f960afe.jpg?v=1757655668","url":"https:\/\/shop.autorenwelt.de\/en\/products\/pectin-hydrogel-copolymers-for-sustained-drug-release-von-yousef-abul-haija","provider":"Autorenwelt Shop","version":"1.0","type":"link"}