{"product_id":"novel-cbd-derivatives-and-their-use-as-anti-inflammatory-agents-von-christeene-haj","title":"Novel CBD derivatives and their use as anti-inflammatory agents","description":"\u003cp\u003eCannabidiol (CBD) is a nonpsychoactive component of cannabis with a high potential for use in several therapeutic areas. It binds very weakly to the CB1 and CB2. It has been evaluated both in vitro and in vivo in anti-inflammatory assays. Thus, it lowers the formation of TNF-¿, a proinflammatory cytokine, in vitro, and was found to be an oral anti-arthritic therapeutic in murine collagen-induced arthritis in vivo. Its numerous potentially therapeutic pharmacological effects may be due in part to its metabolites. Indeed, a derivative of such a metabolite, CBD-dimethylheptyl (DMH)-7-oic-acid (HU-320) is more potent than CBD as an anti-arthritic agent in the above model of CIA. Several synthetic enantiomeric (+)-CBD derivatives, have been found to be bind to the CB1 receptor, but have only peripheral action and may not be able to cross the blood-brain barrier while its 7-OH-counterpart , (+)-7-OH-cannabidiol-DMH does cross the blood-brain barrier. The lack of central effects may make possible the development of such derivative as peripheral anti-inflammatory drugs.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659781971\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659781971","offer_id":39434592223325,"sku":"9783659781971","price":61.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/5eca0bc6-92e3-480b-9272-9015d30d91d4.jpg?v=1760160282","url":"https:\/\/shop.autorenwelt.de\/en\/products\/novel-cbd-derivatives-and-their-use-as-anti-inflammatory-agents-von-christeene-haj","provider":"Autorenwelt Shop","version":"1.0","type":"link"}