{"product_id":"non-canonical-pre-tcr-signaling-during-t-cell-development-von-damian-maseda-caballero","title":"Non-canonical pre-TCR signaling during T cell development","description":"\u003cp\u003eT cells undergoing maturation in the thymus need to receive a pre-TCR-delivered signal to undergo ¿-selection and develop further properly. The pre-TCR is composed of a constitutively expressed pre-T¿ (pT¿) chain and a de novo expressed TCR¿ chain. A productive recombination of the TCR¿ chain is mandatory to overcome the first checkpoint that controls T cells survival. However, in a very low but consistent extent, thymocytes lacking a canonical pre-TCR can differentiate further. We show that thymocytes lacking a classical pre-TCR can survive and differentiate to later developmental stages. Besides, signaling through a pT¿-less TCR is enough to achieve Ca2+ influx and NF-¿B activation. In addition, we demonstrate that the mechanisms underlying cell death of thymocytes in conditions of proteasome inhibition are in great extent independent of NF-¿B activation and pre-TCR or TCR signaling, and are rather dependent on triggering the pro-apoptotic terminal UPR.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659857614\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659857614","offer_id":39435464966237,"sku":"9783659857614","price":39.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/c64d780a-8cf3-47ea-8e67-9c998d4dcce5.jpg?v=1759037498","url":"https:\/\/shop.autorenwelt.de\/en\/products\/non-canonical-pre-tcr-signaling-during-t-cell-development-von-damian-maseda-caballero","provider":"Autorenwelt Shop","version":"1.0","type":"link"}